2fxa

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[[Image:2fxa.gif|left|200px]]
 
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{{Structure
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==Structure of the Protease Production Regulatory Protein hpr from Bacillus subtilis.==
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|PDB= 2fxa |SIZE=350|CAPTION= <scene name='initialview01'>2fxa</scene>, resolution 2.40&Aring;
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<StructureSection load='2fxa' size='340' side='right'caption='[[2fxa]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene> and <scene name='pdbligand=1PE:PENTAETHYLENE GLYCOL'>1PE</scene>
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<table><tr><td colspan='2'>[[2fxa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FXA FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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|GENE= hpr, catA, scoC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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}}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hpr, catA, scoC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Bacillus globigii" Migula 1900])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fxa OCA], [https://pdbe.org/2fxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fxa RCSB], [https://www.ebi.ac.uk/pdbsum/2fxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fxa ProSAT], [https://www.topsan.org/Proteins/MCSG/2fxa TOPSAN]</span></td></tr>
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'''Structure of the Protease Production Regulatory Protein hpr from Bacillus subtilis.'''
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/HPR_BACSU HPR_BACSU]] Negative regulator of protease production and sporulation. Acts by binding directly to the promoter of protease genes (aprE and nprE), and by repressing oligopeptide permease operons (appABCDF and oppABCDF), thereby preventing uptake of oligopeptides required for initiation of sporulation. Acts with SinR as a corepressor of epr expression.<ref>PMID:1906467</ref> <ref>PMID:10383984</ref> <ref>PMID:16923912</ref>
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==About this Structure==
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== Evolutionary Conservation ==
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2FXA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXA OCA].
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Bacillus subtilis]]
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Check<jmol>
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[[Category: Single protein]]
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<jmolCheckbox>
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[[Category: Cuff, M E.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fx/2fxa_consurf.spt"</scriptWhenChecked>
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[[Category: Edwards, A.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Joachimiak, A.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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</jmolCheckbox>
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[[Category: Savchenko, A.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fxa ConSurf].
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[[Category: Skarina, T.]]
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<div style="clear:both"></div>
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[[Category: 1PE]]
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== References ==
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[[Category: EDO]]
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<references/>
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[[Category: P6G]]
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__TOC__
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[[Category: PGE]]
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</StructureSection>
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[[Category: bacillus subtili]]
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[[Category: Bacillus globigii migula 1900]]
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[[Category: hpr]]
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[[Category: Large Structures]]
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[[Category: mcsg]]
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[[Category: Cuff, M E]]
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[[Category: midwest center for structural genomic]]
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[[Category: Edwards, A]]
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[[Category: protease porduction]]
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[[Category: Joachimiak, A]]
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[[Category: protein structure initiative]]
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[[Category: Structural genomic]]
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[[Category: psi]]
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[[Category: Savchenko, A]]
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[[Category: regulation]]
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[[Category: Skarina, T]]
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[[Category: structural genomic]]
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[[Category: Bacillus subtili]]
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[[Category: Hpr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:57:52 2008''
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[[Category: Mcsg]]
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[[Category: Protease porduction]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Regulation]]
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[[Category: Transcription]]

Current revision

Structure of the Protease Production Regulatory Protein hpr from Bacillus subtilis.

PDB ID 2fxa

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OCA

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