3qs2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:49, 21 February 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal structure of the biofilm forming subunit of the E. coli common pilus: full length domain swapped dimer of EcpA==
==Crystal structure of the biofilm forming subunit of the E. coli common pilus: full length domain swapped dimer of EcpA==
-
<StructureSection load='3qs2' size='340' side='right' caption='[[3qs2]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
+
<StructureSection load='3qs2' size='340' side='right'caption='[[3qs2]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3qs2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QS2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QS2 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3qs2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_CFT073 Escherichia coli CFT073]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QS2 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3qs3|3qs3]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">matB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qs2 OCA], [https://pdbe.org/3qs2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qs2 RCSB], [https://www.ebi.ac.uk/pdbsum/3qs2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qs2 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qs2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qs2 RCSB], [http://www.ebi.ac.uk/pdbsum/3qs2 PDBsum]</span></td></tr>
+
</table>
</table>
-
<div style="background-color:#fffaf0;">
+
== Function ==
-
== Publication Abstract from PubMed ==
+
[https://www.uniprot.org/uniprot/ECPA_ECOL6 ECPA_ECOL6] Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Major subunit of the fimbria.<ref>PMID:22355107</ref>
-
Bacteria have evolved a variety of mechanisms for developing community-based biofilms. These bacterial aggregates are of clinical importance, as they are a major source of recurrent disease. Bacterial surface fibers (pili) permit adherence to biotic and abiotic substrates, often in a highly specific manner. The Escherichia coli common pilus (ECP) represents a remarkable family of extracellular fibers that are associated with both disease-causing and commensal strains. ECP plays a dual role in early-stage biofilm development and host cell recognition. Despite being the most common fimbrial structure, relatively little is known regarding its biogenesis, architecture, and function. Here we report atomic-resolution insight into the biogenesis and architecture of ECP. We also derive a structural model for entwined ECP fibers that not only illuminates interbacteria communication during biofilm formation but also provides a useful foundation for the design of novel nanofibers.
+
-
 
+
-
Structural insights into the biogenesis and biofilm formation by the Escherichia coli common pilus.,Garnett JA, Martinez-Santos VI, Saldana Z, Pape T, Hawthorne W, Chan J, Simpson PJ, Cota E, Puente JL, Giron JA, Matthews S Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3950-5. Epub 2012 Feb 21. PMID:22355107<ref>PMID:22355107</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Escherichia coli]]
+
[[Category: Escherichia coli CFT073]]
-
[[Category: Garnett, J A]]
+
[[Category: Large Structures]]
-
[[Category: Matthews, S J]]
+
[[Category: Garnett JA]]
-
[[Category: Adhesion]]
+
[[Category: Matthews SJ]]
-
[[Category: Biofilm]]
+
-
[[Category: Cell adhesion]]
+
-
[[Category: Extracellular membrane]]
+
-
[[Category: Ig-like fold]]
+
-
[[Category: Immunoglobulin-like fold]]
+
-
[[Category: Intermolecular and hydrophobic abiotic surface binding]]
+
-
[[Category: Major pilin domain involved in biofilm]]
+
-
[[Category: Pilin]]
+

Current revision

Crystal structure of the biofilm forming subunit of the E. coli common pilus: full length domain swapped dimer of EcpA

PDB ID 3qs2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3qs2"
Personal tools