3rx9

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==3D structure of SciN from an Escherichia coli Patotype==
==3D structure of SciN from an Escherichia coli Patotype==
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<StructureSection load='3rx9' size='340' side='right' caption='[[3rx9]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
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<StructureSection load='3rx9' size='340' side='right'caption='[[3rx9]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3rx9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RX9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RX9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3rx9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_55989 Escherichia coli 55989]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RX9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RX9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EC55989_3320, NC_011748.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rx9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rx9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rx9 RCSB], [http://www.ebi.ac.uk/pdbsum/3rx9 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rx9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rx9 OCA], [https://pdbe.org/3rx9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rx9 RCSB], [https://www.ebi.ac.uk/pdbsum/3rx9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rx9 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/B7LFS8_ECO55 B7LFS8_ECO55]
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Type VI secretion systems (T6SS) are trans-envelope machines dedicated to the secretion of virulence factors into eukaryotic or prokaryotic cells, therefore required for pathogenesis and/or for competition towards neighboring bacteria. The T6SS apparatus resembles the injection device of bacteriophage T4, and is anchored to the cell envelope through a membrane complex. This membrane complex is composed of the TssL, TssM and TagL inner membrane anchored proteins and of the TssJ outer membrane lipoprotein. Here, we report the crystal structure of the enteroaggregative Escherichia coli Sci1 TssJ lipoprotein, a two four-stranded beta-sheets protein that exhibits a transthyretin fold with an additional alpha-helical domain and a protruding loop. We showed that TssJ contacts TssM through this loop since a loop depleted mutant failed to interact with TssM in vitro or in vivo. Biophysical analysis of TssM and TssJ-TssM interaction suggest a structural model of the membrane-anchored outer shell of T6SS. Collectively, our results provide an improved understanding of T6SS assembly and encourage structure-aided drug design of novel antimicrobials targeting T6SS.
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Towards a Structural Comprehension of Bacterial Type VI Secretion Systems: Characterization of the TssJ-TssM Complex of an Escherichia coli Pathovar.,Felisberto-Rodrigues C, Durand E, Aschtgen MS, Blangy S, Ortiz-Lombardia M, Douzi B, Cambillau C, Cascales E PLoS Pathog. 2011 Nov;7(11):e1002386. Epub 2011 Nov 10. PMID:22102820<ref>PMID:22102820</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Escherichia coli 55989]]
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[[Category: Aschtgen, M S]]
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[[Category: Large Structures]]
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[[Category: Blangy, S]]
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[[Category: Aschtgen M-S]]
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[[Category: Cambillau, C]]
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[[Category: Blangy S]]
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[[Category: Cascales, E]]
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[[Category: Cambillau C]]
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[[Category: Douzy, B]]
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[[Category: Cascales E]]
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[[Category: Durand, E]]
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[[Category: Douzy B]]
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[[Category: Felisberto-Rodrigues, C]]
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[[Category: Durand E]]
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[[Category: Ortiz-Lombardia, M]]
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[[Category: Felisberto-Rodrigues C]]
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[[Category: Lipid binding protein]]
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[[Category: Ortiz-Lombardia M]]
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[[Category: Lipoprotein]]
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[[Category: Scis]]
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[[Category: T6ss assembly]]
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Current revision

3D structure of SciN from an Escherichia coli Patotype

PDB ID 3rx9

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