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2gjc

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[[Image:2gjc.gif|left|200px]]
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#REDIRECT [[3fpz]] This PDB entry is obsolete and replaced by 3fpz
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{{Structure
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|PDB= 2gjc |SIZE=350|CAPTION= <scene name='initialview01'>2gjc</scene>, resolution 1.82&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=AHZ:ADENOSINE DIPHOSPHATE 5-(BETA-ETHYL)-4-METHYL-THIAZOLE-2-CARBOXYLIC ACID'>AHZ</scene>
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|ACTIVITY=
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|GENE= THI4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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}}
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'''Crystal Structure of Thiazole Synthase in Saccharomyces cerevisiae at 1.82 A resolution'''
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==Overview==
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The structure of thiazole synthase (Thi4) from Saccharomyces cerevisiae was determined to 1.8 A resolution. Thi4 exists as an octamer with two monomers in the asymmetric unit. The structure reveals the presence of a tightly bound adenosine diphospho-5-(beta-ethyl)-4-methylthiazole-2-carboxylic acid at the active site. The isolation of this reaction product identifies NAD as the most likely precursor and provides the first mechanistic insights into the biosynthesis of the thiamin thiazole in eukaryotes. Additionally, the Thi4 structure reveals the first protein structure with a GR(2) domain that binds NAD instead of FAD, raising interesting questions about how this protein evolved from a flavoenzyme to a NAD binding enzyme.
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==About this Structure==
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2GJC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJC OCA].
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==Reference==
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Structural insights into the function of the thiamin biosynthetic enzyme Thi4 from Saccharomyces cerevisiae., Jurgenson CT, Chatterjee A, Begley TP, Ealick SE, Biochemistry. 2006 Sep 19;45(37):11061-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16964967 16964967]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Begley, T P.]]
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[[Category: Chatterjee, A.]]
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[[Category: Ealick, S E.]]
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[[Category: Jurgenson, C T.]]
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[[Category: AHZ]]
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[[Category: glutathione reductase type ii family]]
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[[Category: mitochondria dna repair]]
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[[Category: thiazole synthase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:05:21 2008''
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Current revision

  1. REDIRECT 3fpz This PDB entry is obsolete and replaced by 3fpz

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