3s1j

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==Crystal structure of acetate-bound hell's gate globin I==
==Crystal structure of acetate-bound hell's gate globin I==
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<StructureSection load='3s1j' size='340' side='right' caption='[[3s1j]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='3s1j' size='340' side='right'caption='[[3s1j]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3s1j]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylacidiphilum_infernorum_v4 Methylacidiphilum infernorum v4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S1J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S1J FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3s1j]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylacidiphilum_infernorum_V4 Methylacidiphilum infernorum V4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S1J FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3s1i|3s1i]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hmp, Minf_1095 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=481448 Methylacidiphilum infernorum V4])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s1j OCA], [https://pdbe.org/3s1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s1j RCSB], [https://www.ebi.ac.uk/pdbsum/3s1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s1j ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s1j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s1j RCSB], [http://www.ebi.ac.uk/pdbsum/3s1j PDBsum]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/B3DUZ7_METI4 B3DUZ7_METI4]
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Hell's Gate globin I (HGbI), a heme-containing protein structurally homologous to mammalian neuroglobins, has been identified from an acidophilic and thermophilic obligate methanotroph, Methylacidiphilum infernorum. HGbI has very high affinity for O(2) and shows barely detectable autoxidation in the pH range of 5.2-8.6 and temperature range of 25-50 degrees C. Examination of the heme pocket by X-ray crystallography and molecular dynamics showed that conformational movements of Tyr29(B10) and Gln50(E7), as well as structural flexibility of the GH loop and H-helix, may play a role in modulating its ligand binding behavior. Bacterial HGbI's unique resistance to the sort of extreme acidity that would extract heme from any other hemoglobin makes it an ideal candidate for comparative structure-function studies of the expanding globin superfamily.
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Hell's Gate globin I: an acid and thermostable bacterial hemoglobin resembling mammalian neuroglobin.,Teh AH, Saito JA, Baharuddin A, Tuckerman JR, Newhouse JS, Kanbe M, Newhouse EI, Rahim RA, Favier F, Didierjean C, Sousa EH, Stott MB, Dunfield PF, Gonzalez G, Gilles-Gonzalez MA, Najimudin N, Alam M FEBS Lett. 2011 Oct 20;585(20):3250-8. Epub 2011 Sep 9. PMID:21925500<ref>PMID:21925500</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Methylacidiphilum infernorum v4]]
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[[Category: Large Structures]]
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[[Category: Alam, M]]
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[[Category: Methylacidiphilum infernorum V4]]
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[[Category: Baharuddin, A]]
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[[Category: Alam M]]
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[[Category: Didierjean, C]]
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[[Category: Baharuddin A]]
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[[Category: Dunfield, P F]]
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[[Category: Didierjean C]]
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[[Category: Favier, F]]
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[[Category: Dunfield PF]]
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[[Category: Gilles-Gonzalez, M A]]
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[[Category: Favier F]]
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[[Category: Gonzalez, G]]
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[[Category: Gilles-Gonzalez MA]]
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[[Category: Kanbe, M]]
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[[Category: Gonzalez G]]
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[[Category: Najimudin, N]]
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[[Category: Kanbe M]]
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[[Category: Newhouse, E I]]
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[[Category: Najimudin N]]
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[[Category: Newhouse, J S]]
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[[Category: Newhouse EI]]
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[[Category: Rahim, R A]]
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[[Category: Newhouse JS]]
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[[Category: Saito, J A]]
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[[Category: Rahim RA]]
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[[Category: Sousa, E H.S]]
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[[Category: Saito JA]]
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[[Category: Stott, M B]]
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[[Category: Sousa EHS]]
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[[Category: Teh, A H]]
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[[Category: Stott MB]]
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[[Category: Tuckerman, J R]]
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[[Category: Teh AH]]
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[[Category: Acetate-bound]]
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[[Category: Tuckerman JR]]
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[[Category: Autoxidation]]
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[[Category: Globin]]
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[[Category: Heme]]
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[[Category: Oxygen storage]]
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[[Category: Oxygen transport]]
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Current revision

Crystal structure of acetate-bound hell's gate globin I

PDB ID 3s1j

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