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3v5s

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==Structure of Sodium/Calcium Exchanger from Methanococcus jannaschii==
==Structure of Sodium/Calcium Exchanger from Methanococcus jannaschii==
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<StructureSection load='3v5s' size='340' side='right' caption='[[3v5s]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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<StructureSection load='3v5s' size='340' side='right'caption='[[3v5s]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3v5s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V5S FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3v5s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii_DSM_2661 Methanocaldococcus jannaschii DSM 2661]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V5S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V5S FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3v5u|3v5u]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MJ0091 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v5s OCA], [https://pdbe.org/3v5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v5s RCSB], [https://www.ebi.ac.uk/pdbsum/3v5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v5s ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v5s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v5s RCSB], [http://www.ebi.ac.uk/pdbsum/3v5s PDBsum]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Y091_METJA Y091_METJA]
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Sodium/calcium (Na(+)/Ca(2+)) exchangers (NCX) are membrane transporters that play an essential role in maintaining the homeostasis of cytosolic Ca(2+) for cell signaling. We demonstrated the Na(+)/Ca(2+)-exchange function of an NCX from Methanococcus jannaschii (NCX_Mj) and report its 1.9 angstrom crystal structure in an outward-facing conformation. Containing 10 transmembrane helices, the two halves of NCX_Mj share a similar structure with opposite orientation. Four ion-binding sites cluster at the center of the protein: one specific for Ca(2+) and three that likely bind Na(+). Two passageways allow for Na(+) and Ca(2+) access to the central ion-binding sites from the extracellular side. Based on the symmetry of NCX_Mj and its ability to catalyze bidirectional ion-exchange reactions, we propose a structure model for the inward-facing NCX_Mj.
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Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger.,Liao J, Li H, Zeng W, Sauer DB, Belmares R, Jiang Y Science. 2012 Feb 10;335(6069):686-90. PMID:22323814<ref>PMID:22323814</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Methanocaldococcus jannaschii]]
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[[Category: Large Structures]]
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[[Category: Belmares, R]]
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[[Category: Methanocaldococcus jannaschii DSM 2661]]
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[[Category: Jiang, Y]]
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[[Category: Belmares R]]
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[[Category: Li, H]]
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[[Category: Jiang Y]]
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[[Category: Liao, J]]
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[[Category: Li H]]
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[[Category: Sauer, D B]]
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[[Category: Liao J]]
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[[Category: Zeng, W]]
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[[Category: Sauer DB]]
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[[Category: Alpha-helical]]
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[[Category: Zeng W]]
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[[Category: Calcium transport]]
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[[Category: Cation binding]]
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[[Category: Metal transport]]
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[[Category: Protein-cation complex]]
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[[Category: Sodium/calcium exchanger]]
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[[Category: Transmembrane protein]]
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Current revision

Structure of Sodium/Calcium Exchanger from Methanococcus jannaschii

PDB ID 3v5s

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