2gl2

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[[Image:2gl2.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of the tetra muntant (T66G,R67G,F68G,Y69G) of bacterial adhesin FadA==
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|PDB= 2gl2 |SIZE=350|CAPTION= <scene name='initialview01'>2gl2</scene>, resolution 2.500&Aring;
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<StructureSection load='2gl2' size='340' side='right'caption='[[2gl2]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2gl2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusobacterium_nucleatum Fusobacterium nucleatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GL2 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gl2 OCA], [https://pdbe.org/2gl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gl2 RCSB], [https://www.ebi.ac.uk/pdbsum/2gl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gl2 ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q5I6B0_FUSNU Q5I6B0_FUSNU]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Fusobacterium nucleatum is a gram-negative anaerobe prevalent in the oral cavity that is associated with periodontal disease, preterm birth and infections in other parts of the human body. The bacteria attach to and invade epithelial and endothelial cells in the gum tissue and elsewhere via a 13.7 kDa adhesin protein FadA (Fusobacterium adhesin A). FadA exists in two forms: the intact form (pre-FadA), consisting of 129 amino acids, and the mature form (mFadA), which lacks an 18-residue signal sequence. Both forms have been expressed in Escherichia coli and purified. mFadA has been crystallized. The crystals belong to the hexagonal space group P6(1) or P6(5), with unit-cell parameters a = b = 59.3, c = 125.7 A and one molecule per asymmetric unit. The crystals exhibit an unusually high solvent content of 74%. Synchrotron X-ray data have been collected to 1.9 A. The crystals are suitable for X-ray structure determination. The crystal structure of FadA may provide a basis for the development of therapeutic agents to combat periodontal disease and other infections associated with F. nucleatum.
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'''Crystal structure of the tetra muntant (T66G,R67G,F68G,Y69G) of bacterial adhesin FadA'''
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Crystallization and preliminary X-ray data of the FadA adhesin from Fusobacterium nucleatum.,Nithianantham S, Xu M, Wu N, Han YW, Shoham M Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt, 12):1215-7. Epub 2006 Nov 4. PMID:17142900<ref>PMID:17142900</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2gl2" style="background-color:#fffaf0;"></div>
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==Overview==
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==See Also==
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Fusobacterium nucleatum is a gram-negative anaerobe prevalent in the oral cavity that is associated with periodontal disease, preterm birth and infections in other parts of the human body. The bacteria attach to and invade epithelial and endothelial cells in the gum tissue and elsewhere via a 13.7 kDa adhesin protein FadA (Fusobacterium adhesin A). FadA exists in two forms: the intact form (pre-FadA), consisting of 129 amino acids, and the mature form (mFadA), which lacks an 18-residue signal sequence. Both forms have been expressed in Escherichia coli and purified. mFadA has been crystallized. The crystals belong to the hexagonal space group P6(1) or P6(5), with unit-cell parameters a = b = 59.3, c = 125.7 A and one molecule per asymmetric unit. The crystals exhibit an unusually high solvent content of 74%. Synchrotron X-ray data have been collected to 1.9 A. The crystals are suitable for X-ray structure determination. The crystal structure of FadA may provide a basis for the development of therapeutic agents to combat periodontal disease and other infections associated with F. nucleatum.
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*[[Adhesin 3D structures|Adhesin 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2GL2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Fusobacterium_nucleatum Fusobacterium nucleatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GL2 OCA].
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__TOC__
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</StructureSection>
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==Reference==
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Crystallization and preliminary X-ray data of the FadA adhesin from Fusobacterium nucleatum., Nithianantham S, Xu M, Wu N, Han YW, Shoham M, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt, 12):1215-7. Epub 2006 Nov 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17142900 17142900]
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[[Category: Fusobacterium nucleatum]]
[[Category: Fusobacterium nucleatum]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Han, Y W.]]
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[[Category: Han YW]]
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[[Category: Nithianantham, S.]]
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[[Category: Nithianantham S]]
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[[Category: Shoham, M.]]
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[[Category: Shoham M]]
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[[Category: Wu, N.]]
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[[Category: Wu N]]
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[[Category: Xu, M.]]
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[[Category: Xu M]]
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[[Category: antiparallel helix-loop-helix]]
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[[Category: fada gly4 mutant]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:05:55 2008''
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Current revision

Crystal structure of the tetra muntant (T66G,R67G,F68G,Y69G) of bacterial adhesin FadA

PDB ID 2gl2

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