3v0b

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==3.9 angstrom crystal structure of BoNT/Ai in complex with NTNHA==
==3.9 angstrom crystal structure of BoNT/Ai in complex with NTNHA==
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<StructureSection load='3v0b' size='340' side='right' caption='[[3v0b]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
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<StructureSection load='3v0b' size='340' side='right'caption='[[3v0b]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3v0b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V0B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V0B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3v0b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V0B FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bont/a, boNT/A, bonta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 Clostridium botulinum]), ant, ntnh ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 Clostridium botulinum])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v0b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v0b RCSB], [http://www.ebi.ac.uk/pdbsum/3v0b PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v0b OCA], [https://pdbe.org/3v0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v0b RCSB], [https://www.ebi.ac.uk/pdbsum/3v0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v0b ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BXA1_CLOBH BXA1_CLOBH] Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3v0b" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Botulinum neurotoxin|Botulinum neurotoxin]]
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*[[Botulinum neurotoxin 3D structures|Botulinum neurotoxin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Clostridium botulinum]]
[[Category: Clostridium botulinum]]
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[[Category: Bigalke, H]]
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[[Category: Large Structures]]
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[[Category: Gu, S]]
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[[Category: Bigalke H]]
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[[Category: Jin, R]]
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[[Category: Gu S]]
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[[Category: Perry, K]]
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[[Category: Jin R]]
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[[Category: Rummel, A]]
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[[Category: Perry K]]
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[[Category: Rumpel, S]]
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[[Category: Rummel A]]
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[[Category: Shoemaker, C B]]
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[[Category: Rumpel S]]
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[[Category: Strotmeier, J]]
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[[Category: Shoemaker CB]]
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[[Category: Zhou, J]]
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[[Category: Strotmeier J]]
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[[Category: Botulinum neurotoxin]]
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[[Category: Zhou J]]
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[[Category: Toxin]]
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[[Category: Vhh free inlocked complex]]
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Current revision

3.9 angstrom crystal structure of BoNT/Ai in complex with NTNHA

PDB ID 3v0b

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