3v7t

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==Crystal Structure of Human Beta-Tryptase Complexed with a Synthetic Inhibitor with a Tropanylamide Scaffold==
==Crystal Structure of Human Beta-Tryptase Complexed with a Synthetic Inhibitor with a Tropanylamide Scaffold==
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<StructureSection load='3v7t' size='340' side='right' caption='[[3v7t]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
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<StructureSection load='3v7t' size='340' side='right'caption='[[3v7t]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3v7t]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V7T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V7T FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3v7t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V7T FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0GX:{(3-EXO)-3-[5-(AMINOMETHYL)-2-FLUOROPHENYL]-8-AZABICYCLO[3.2.1]OCT-8-YL}(4-BROMO-3-METHYL-5-PROPOXYTHIOPHEN-2-YL)METHANONE'>0GX</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TPSB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0GX:{(3-EXO)-3-[5-(AMINOMETHYL)-2-FLUOROPHENYL]-8-AZABICYCLO[3.2.1]OCT-8-YL}(4-BROMO-3-METHYL-5-PROPOXYTHIOPHEN-2-YL)METHANONE'>0GX</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v7t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v7t RCSB], [http://www.ebi.ac.uk/pdbsum/3v7t PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v7t OCA], [https://pdbe.org/3v7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v7t RCSB], [https://www.ebi.ac.uk/pdbsum/3v7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v7t ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRYB2_HUMAN TRYB2_HUMAN] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3v7t" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Colonna, C]]
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[[Category: Large Structures]]
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[[Category: Michot, N]]
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[[Category: Colonna C]]
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[[Category: Zhang, Y]]
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[[Category: Michot N]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Zhang Y]]
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[[Category: Protein-ligand complex]]
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[[Category: Serine protease]]
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[[Category: Tetramer]]
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[[Category: Tryptase]]
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Current revision

Crystal Structure of Human Beta-Tryptase Complexed with a Synthetic Inhibitor with a Tropanylamide Scaffold

PDB ID 3v7t

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