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3r8k

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==Crystal structure of human SOUL protein (hexagonal form)==
==Crystal structure of human SOUL protein (hexagonal form)==
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<StructureSection load='3r8k' size='340' side='right' caption='[[3r8k]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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<StructureSection load='3r8k' size='340' side='right'caption='[[3r8k]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3r8k]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R8K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3R8K FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3r8k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R8K FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3r8j|3r8j]], [[3r85|3r85]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C6orf34, HEBP2, SOUL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r8k OCA], [https://pdbe.org/3r8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r8k RCSB], [https://www.ebi.ac.uk/pdbsum/3r8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r8k ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r8k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3r8k RCSB], [http://www.ebi.ac.uk/pdbsum/3r8k PDBsum]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/HEBP2_HUMAN HEBP2_HUMAN] Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. Does not bind hemin.<ref>PMID:17098234</ref>
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The SOUL protein is known to induce apoptosis by provoking the mitochondrial permeability transition and a sequence homologous to the Bcl-2 homology 3 (BH3) domains has been recently identified in it thus making it a potential new member of the BH3-only protein family. Here we present NMR, SPR and crystallographic evidence that a peptide spanning SOUL residues 147 - 172 interacts with the anti-apoptotic protein Bcl-xL. We have crystallized SOUL alone and the complex of its BH3 domain peptide with Bcl-xL and solved their three-dimensional structures. The SOUL monomer is a single domain organized as a distorted beta barrel with eight anti-parallel strands and two alpha helices. The BH3 domain extends across 15 residues at the end of the second helix and 8 amino acids in the chain following it. There are important structural differences in the BH3 domain in the intact SOUL molecule and the same sequence bound to Bcl-xL.
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Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL.,Ambrosi E, Capaldi S, Bovi M, Saccomani G, Perduca M, Monaco HL Biochem J. 2011 Jun 6. PMID:21639858<ref>PMID:21639858</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ambrosi, E K]]
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[[Category: Large Structures]]
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[[Category: Bovi, M]]
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[[Category: Ambrosi EK]]
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[[Category: Capaldi, S]]
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[[Category: Bovi M]]
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[[Category: Monaco, H L]]
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[[Category: Capaldi S]]
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[[Category: Perduca, M]]
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[[Category: Monaco HL]]
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[[Category: Saccomani, G]]
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[[Category: Perduca M]]
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[[Category: Apoptosis]]
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[[Category: Saccomani G]]
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[[Category: Hebp family]]
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[[Category: Soul protein]]
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Current revision

Crystal structure of human SOUL protein (hexagonal form)

PDB ID 3r8k

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