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2gq6

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[[Image:2gq6.gif|left|200px]]
 
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{{Structure
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==Crystal structure of an RNA racemate==
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|PDB= 2gq6 |SIZE=350|CAPTION= <scene name='initialview01'>2gq6</scene>, resolution 1.3&Aring;
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<StructureSection load='2gq6' size='340' side='right'caption='[[2gq6]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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<table><tr><td colspan='2'>[[2gq6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GQ6 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0C:L-CYTIDINE-5-MONOPHOSPHATE'>0C</scene>, <scene name='pdbligand=0G:L-GUANOSINE-5-MONOPHOSPHATE'>0G</scene>, <scene name='pdbligand=0U:L-URIDINE-5-MONOPHOSPHATE'>0U</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gq6 OCA], [https://pdbe.org/2gq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gq6 RCSB], [https://www.ebi.ac.uk/pdbsum/2gq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gq6 ProSAT]</span></td></tr>
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</table>
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'''Crystal structure of an RNA racemate'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Betzel C]]
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The racemate of the RNA duplex r(CUGGGCGG).r(CCGCCUGG) from Thermus flavus 5S rRNA has been crystallized and examined by X-ray crystallography. The space group is P1(_) with approximate unit-cell parameters a = 26.5, b = 38.0, c = 45.4 Angstrom, alpha = 113.1, beta = 100.5, gamma = 93.3 degrees. The structure was solved by molecular replacement. There are four RNA duplexes in the unit cell. The crystal lattice consists of columns of RNA duplexes. The duplexes are stacked end-to-end and are stabilized by intermolecular base-stacking interactions. Within each column the L-duplexes and D-duplexes are stacked alternately. Every other duplex in each stack has two alternative conformations, approximately equally occupied, corresponding to molecules oriented in opposite directions. Neighbouring columns are related by the crystallographic centre of symmetry. The unit cell also contains approximately 250 ordered water molecules and six ordered calcium ions. A glycerol molecule is visible in the minor groove interacting with a guanosine residue.
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[[Category: Erdmann VA]]
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[[Category: Klussmann S]]
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==About this Structure==
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[[Category: Perbandt M]]
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2GQ6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQ6 OCA].
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[[Category: Rypniewski W]]
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[[Category: Vallazza M]]
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==Reference==
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The first crystal structure of an RNA racemate., Rypniewski W, Vallazza M, Perbandt M, Klussmann S, Delucas LJ, Betzel C, Erdmann VA, Acta Crystallogr D Biol Crystallogr. 2006 Jun;62(Pt 6):659-64. Epub 2006, May 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16699193 16699193]
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[[Category: Protein complex]]
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[[Category: Betzel, C.]]
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[[Category: Erdmann, V A.]]
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[[Category: Klussmann, S.]]
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[[Category: Perbandt, M.]]
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[[Category: Rypniewski, W.]]
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[[Category: Vallazza, M.]]
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[[Category: CA]]
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[[Category: GOL]]
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[[Category: double helix]]
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[[Category: racemate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:07:40 2008''
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Current revision

Crystal structure of an RNA racemate

PDB ID 2gq6

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