3v0a

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==2.7 angstrom crystal structure of BoNT/Ai in complex with NTNHA==
==2.7 angstrom crystal structure of BoNT/Ai in complex with NTNHA==
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<StructureSection load='3v0a' size='340' side='right' caption='[[3v0a]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='3v0a' size='340' side='right'caption='[[3v0a]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3v0a]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V0A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V0A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3v0a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V0A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V0A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.703&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3v0b|3v0b]], [[3v0c|3v0c]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bont/a, boNT/A, bonta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 Clostridium botulinum]), ant, ntnh ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 Clostridium botulinum])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v0a OCA], [https://pdbe.org/3v0a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v0a RCSB], [https://www.ebi.ac.uk/pdbsum/3v0a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v0a ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v0a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v0a RCSB], [http://www.ebi.ac.uk/pdbsum/3v0a PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BXAN_CLOBO BXAN_CLOBO] Assembles with botulinum neurotoxin type A (BoNT/A) and protects it against pH-mediated inactivation or protease activity at pH 2.6 (the pH of the animal gastrointestinal tract) but not at pH 6.0 (PubMed:22363010). Necessary for neurotoxicity.<ref>PMID:22363010</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3v0a" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Antibody|Antibody]]
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Botulinum neurotoxin|Botulinum neurotoxin]]
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*[[Botulinum neurotoxin 3D structures|Botulinum neurotoxin 3D structures]]
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Clostridium botulinum]]
[[Category: Clostridium botulinum]]
[[Category: Lama glama]]
[[Category: Lama glama]]
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[[Category: Bigalke, H]]
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[[Category: Large Structures]]
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[[Category: Gu, S]]
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[[Category: Bigalke H]]
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[[Category: Jin, R]]
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[[Category: Gu S]]
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[[Category: Perry, K]]
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[[Category: Jin R]]
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[[Category: Rummel, A]]
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[[Category: Perry K]]
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[[Category: Rumpel, S]]
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[[Category: Rummel A]]
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[[Category: Shoemaker, C B]]
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[[Category: Rumpel S]]
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[[Category: Strotmeier, J]]
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[[Category: Shoemaker CB]]
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[[Category: Zhou, J]]
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[[Category: Strotmeier J]]
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[[Category: Botulinum neurotoxin]]
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[[Category: Zhou J]]
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[[Category: Neurotoxin associated protein]]
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[[Category: Ntnha]]
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[[Category: Progenitor toxin complex]]
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[[Category: Toxin]]
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[[Category: Vhh bound interlocked complex]]
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Current revision

2.7 angstrom crystal structure of BoNT/Ai in complex with NTNHA

PDB ID 3v0a

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