3vvx

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==Crystal Strucuture of RamR (Transcriptional Regurator of TetR Family) from Salmonella Typhimurium==
==Crystal Strucuture of RamR (Transcriptional Regurator of TetR Family) from Salmonella Typhimurium==
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<StructureSection load='3vvx' size='340' side='right' caption='[[3vvx]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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<StructureSection load='3vvx' size='340' side='right'caption='[[3vvx]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3vvx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium_str._14028s Salmonella enterica subsp. enterica serovar typhimurium str. 14028s]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VVX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3vvx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._14028S Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VVX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vvy|3vvy]], [[3vvz|3vvz]], [[3vw0|3vw0]], [[3vw1|3vw1]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STM0580, STM14_0676 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=588858 Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vvx OCA], [https://pdbe.org/3vvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vvx RCSB], [https://www.ebi.ac.uk/pdbsum/3vvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vvx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vvx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vvx RCSB], [http://www.ebi.ac.uk/pdbsum/3vvx PDBsum]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A0A0F6AY66_SALT1 A0A0F6AY66_SALT1]
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RamR is a transcriptional repressor of the gene-encoding RamA protein, which controls the expression of the multidrug efflux system genes acrAB-tolC. RamR is an important multidrug-resistance factor, however, its structure and the identity of the molecules to which it responds have been unknown. Here, we report the crystal structure of RamR in complex with multiple drugs, including berberine, crystal violet, dequalinium, ethidium bromide and rhodamine 6G. All compounds are found to interact with Phe155 of RamR, and each compound is surrounded by different amino acid residues. Binding of these compounds to RamR reduces its DNA-binding affinity, which results in the increased expression of ramA. Our results reveal significant flexibility in the substrate-recognition region of RamR, which regulates the bacterial efflux participating in multidrug resistance.
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The crystal structure of multidrug-resistance regulator RamR with multiple drugs.,Yamasaki S, Nikaido E, Nakashima R, Sakurai K, Fujiwara D, Fujii I, Nishino K Nat Commun. 2013 Jun 26;4:2078. doi: 10.1038/ncomms3078. PMID:23800819<ref>PMID:23800819</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Salmonella enterica subsp. enterica serovar typhimurium str. 14028s]]
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[[Category: Large Structures]]
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[[Category: Nakashima, R]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]]
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[[Category: Nikaido, E]]
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[[Category: Nakashima R]]
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[[Category: Nishino, K]]
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[[Category: Nikaido E]]
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[[Category: Sakurai, K]]
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[[Category: Nishino K]]
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[[Category: Yamaguchi, A]]
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[[Category: Sakurai K]]
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[[Category: Yamasaki, S]]
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[[Category: Yamaguchi A]]
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[[Category: Dna binding]]
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[[Category: Yamasaki S]]
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[[Category: Hth-motif]]
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[[Category: Tetr transcriptional regulator family]]
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[[Category: Transcription regulator]]
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[[Category: Transcriptional regurator]]
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Current revision

Crystal Strucuture of RamR (Transcriptional Regurator of TetR Family) from Salmonella Typhimurium

PDB ID 3vvx

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