This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3vkc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:24, 8 November 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal structure of MoeO5 soaked with pyrophosphate==
==Crystal structure of MoeO5 soaked with pyrophosphate==
-
<StructureSection load='3vkc' size='340' side='right' caption='[[3vkc]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
+
<StructureSection load='3vkc' size='340' side='right'caption='[[3vkc]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3vkc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_ghanaensis Streptomyces ghanaensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VKC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VKC FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3vkc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_viridosporus_ATCC_14672 Streptomyces viridosporus ATCC 14672]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VKC FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FPQ:(2R)-3-(PHOSPHONOOXY)-2-{[(2Z,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIEN-1-YL]OXY}PROPANOIC+ACID'>FPQ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.66&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vk5|3vk5]], [[3vka|3vka]], [[3vkb|3vkb]], [[3vkd|3vkd]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPQ:(2R)-3-(PHOSPHONOOXY)-2-{[(2Z,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIEN-1-YL]OXY}PROPANOIC+ACID'>FPQ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">moeO5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=35758 Streptomyces ghanaensis])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vkc OCA], [https://pdbe.org/3vkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vkc RCSB], [https://www.ebi.ac.uk/pdbsum/3vkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vkc ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vkc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vkc RCSB], [http://www.ebi.ac.uk/pdbsum/3vkc PDBsum]</span></td></tr>
+
</table>
</table>
-
<div style="background-color:#fffaf0;">
+
== Function ==
-
== Publication Abstract from PubMed ==
+
[https://www.uniprot.org/uniprot/A0A011_STRVD A0A011_STRVD]
-
New antibiotics are needed because of the increasing occurrence of multidrug resistance, as seen in Staphylococcus aureus (MRSA). The initiating step of the biosynthesis of the next-generation drug moenomycin is catalyzed by MoeO5, which is a prenyltransferase with triose-phosphate-isomerase barrel structure as was shown by E. Oldfield, R.-T. Guo, and co-workers in their Communication (DOI:10.1002/anie.201108002). The transferred farnesyl group undergoes a trans-to-cis conversion in its first double bond.
+
-
 
+
-
Insights into the Mechanism of the Antibiotic-Synthesizing Enzyme MoeO5 from Crystal Structures of Different Complexes.,Ren F, Ko TP, Feng X, Huang CH, Chan HC, Hu Y, Wang K, Ma Y, Liang PH, Wang AH, Oldfield E, Guo RT Angew Chem Int Ed Engl. 2012 Mar 20. doi: 10.1002/anie.201201339. PMID:22434765<ref>PMID:22434765</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Streptomyces ghanaensis]]
+
[[Category: Large Structures]]
-
[[Category: Guo, R T]]
+
[[Category: Streptomyces viridosporus ATCC 14672]]
-
[[Category: Huang, C H]]
+
[[Category: Guo R-T]]
-
[[Category: Ko, T P]]
+
[[Category: Huang C-H]]
-
[[Category: Ren, F]]
+
[[Category: Ko T-P]]
-
[[Category: Tim barrel]]
+
[[Category: Ren F]]
-
[[Category: Transferase]]
+

Current revision

Crystal structure of MoeO5 soaked with pyrophosphate

PDB ID 3vkc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3vkc"
Personal tools