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3ujm

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==Crystal structure of the NTF2-like domain of the Drosophila melanogaster Rasputin protein==
==Crystal structure of the NTF2-like domain of the Drosophila melanogaster Rasputin protein==
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<StructureSection load='3ujm' size='340' side='right' caption='[[3ujm]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
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<StructureSection load='3ujm' size='340' side='right'caption='[[3ujm]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ujm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UJM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ujm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UJM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.741&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rin, CG9412 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ujm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ujm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ujm RCSB], [http://www.ebi.ac.uk/pdbsum/3ujm PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ujm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ujm OCA], [https://pdbe.org/3ujm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ujm RCSB], [https://www.ebi.ac.uk/pdbsum/3ujm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ujm ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q9VFT4_DROME Q9VFT4_DROME]
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The crystal structure of the NTF2-like domain of the Drosophila homolog of Ras GTPase SH3 Binding Protein (G3BP), Rasputin, was determined at 2.7A resolution. The overall structure is highly similar to nuclear transport factor 2: It is a homodimer comprised of a beta-sheet and three alpha-helices forming a cone-like shape. However, known binding sites for RanGDP and FxFG containing peptides show electrostatic and steric differences compared to nuclear transport factor 2. A HEPES molecule bound in the structure suggests a new, and possibly physiologically relevant, ligand binding site.
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Crystal structure of the Rasputin NTF2-like domain from Drosophila melanogaster.,Vognsen T, Kristensen O Biochem Biophys Res Commun. 2012 Mar 30;420(1):188-92. Epub 2012 Mar 3. PMID:22414690<ref>PMID:22414690</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Kristensen, O]]
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[[Category: Large Structures]]
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[[Category: Vognsen, T]]
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[[Category: Kristensen O]]
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[[Category: Ntf2-like fold]]
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[[Category: Vognsen T]]
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[[Category: Ras signaling]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of the NTF2-like domain of the Drosophila melanogaster Rasputin protein

PDB ID 3ujm

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