4fes

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==Structure of OSH4 in complex with cholesterol analogs==
==Structure of OSH4 in complex with cholesterol analogs==
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<StructureSection load='4fes' size='340' side='right' caption='[[4fes]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='4fes' size='340' side='right'caption='[[4fes]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4fes]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FES OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FES FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4fes]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FES FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0T9:(3S,8S,9S,10R,13S,14S,17R)-3-HYDROXY-10,13-DIMETHYL-17-[(2S,6S)-6-METHYL-3-OXOOCTAN-2-YL]-1,2,3,4,7,8,9,10,11,12,13,14,15,17-TETRADECAHYDRO-16H-CYCLOPENTA[A]PHENANTHREN-16-ONE'>0T9</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zhy|1zhy]], [[4f4b|4f4b]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0T9:(3S,8S,9S,10R,13S,14S,17R)-3-HYDROXY-10,13-DIMETHYL-17-[(2S,6S)-6-METHYL-3-OXOOCTAN-2-YL]-1,2,3,4,7,8,9,10,11,12,13,14,15,17-TETRADECAHYDRO-16H-CYCLOPENTA[A]PHENANTHREN-16-ONE'>0T9</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KES1, OSH4, YPL145C, LPI3C, P2614 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fes OCA], [https://pdbe.org/4fes PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fes RCSB], [https://www.ebi.ac.uk/pdbsum/4fes PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fes ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fes OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fes RCSB], [http://www.ebi.ac.uk/pdbsum/4fes PDBsum]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/KES1_YEAST KES1_YEAST] Plays a role in ergosterol synthesis.
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We have synthesized 16,22-diketocholesterol, a novel ligand for oxysterol-binding protein Osh4, and determined X-ray structure of the diketocholesterol in complex with Osh4. The X-ray structure shows that alpha7 helix of Osh4 assumes open conformation while the rest of Osh4, closed conformation, implying this diketocholesterol-bound Osh4 structure may represent a structural intermediate between the two conformations.
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Synthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4.,Koag MC, Cheun Y, Kou Y, Ouzon-Shubeita H, Min K, Monzingo AF, Lee S Steroids. 2013 Jun 10;78(9):938-944. doi: 10.1016/j.steroids.2013.05.016. PMID:23756172<ref>PMID:23756172</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==See Also==
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</div>
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*[[Oxysterol-binding protein homolog|Oxysterol-binding protein homolog]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Saccharomyces cerevisiae s288c]]
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[[Category: Large Structures]]
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[[Category: Cheun, Y]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Koag, M C]]
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[[Category: Cheun Y]]
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[[Category: Lee, S]]
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[[Category: Koag MC]]
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[[Category: Monzingo, A F]]
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[[Category: Lee S]]
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[[Category: Lipid binding protein]]
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[[Category: Monzingo AF]]
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[[Category: Oxysterol]]
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[[Category: Sterol binding protein]]
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Current revision

Structure of OSH4 in complex with cholesterol analogs

PDB ID 4fes

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