4giw

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==Crystal structure of the RUN domain of human NESCA==
==Crystal structure of the RUN domain of human NESCA==
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<StructureSection load='4giw' size='340' side='right' caption='[[4giw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='4giw' size='340' side='right'caption='[[4giw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4giw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GIW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GIW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4giw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GIW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GIW FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NESCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4giw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4giw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4giw RCSB], [http://www.ebi.ac.uk/pdbsum/4giw PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4giw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4giw OCA], [https://pdbe.org/4giw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4giw RCSB], [https://www.ebi.ac.uk/pdbsum/4giw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4giw ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RUSC1_HUMAN RUSC1_HUMAN] Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF-dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway.<ref>PMID:19365808</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4giw" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bai, L]]
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[[Category: Large Structures]]
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[[Category: Jiang, T]]
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[[Category: Bai L]]
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[[Category: Sun, Q]]
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[[Category: Jiang T]]
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[[Category: Nf-kb pathway]]
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[[Category: Sun Q]]
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[[Category: Ngf-trka signaling pathway]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of the RUN domain of human NESCA

PDB ID 4giw

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OCA

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