4bw2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:06, 9 May 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand==
==The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand==
-
<StructureSection load='4bw2' size='340' side='right' caption='[[4bw2]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
+
<StructureSection load='4bw2' size='340' side='right'caption='[[4bw2]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4bw2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BW2 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4bw2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BW2 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UTH:4-((2-(TERT-BUTYL)PHENYL)AMINO)-7-(3,5-DIMETHYLISOXAZOL-4-YL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC+ACID'>UTH</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bw1|4bw1]], [[4bw3|4bw3]], [[4bw4|4bw4]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UTH:4-((2-(TERT-BUTYL)PHENYL)AMINO)-7-(3,5-DIMETHYLISOXAZOL-4-YL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC+ACID'>UTH</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bw2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bw2 RCSB], [http://www.ebi.ac.uk/pdbsum/4bw2 PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bw2 OCA], [https://pdbe.org/4bw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bw2 RCSB], [https://www.ebi.ac.uk/pdbsum/4bw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bw2 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 20:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4bw2" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Bamborough, P]]
+
[[Category: Large Structures]]
-
[[Category: Bouillot, A]]
+
[[Category: Bamborough P]]
-
[[Category: Chung, C]]
+
[[Category: Bouillot A]]
-
[[Category: Delannee, D]]
+
[[Category: Chung C]]
-
[[Category: Dudit, Y]]
+
[[Category: Delannee D]]
-
[[Category: Gellibert, F]]
+
[[Category: Dudit Y]]
-
[[Category: Huet, P]]
+
[[Category: Gellibert F]]
-
[[Category: Krysa, G]]
+
[[Category: Huet P]]
-
[[Category: Lamotte, Y]]
+
[[Category: Krysa G]]
-
[[Category: Lewis, A]]
+
[[Category: Lamotte Y]]
-
[[Category: Mirguet, O]]
+
[[Category: Lewis A]]
-
[[Category: Nicodeme, E]]
+
[[Category: Mirguet O]]
-
[[Category: Trottet, L]]
+
[[Category: Nicodeme E]]
-
[[Category: Witherington, J]]
+
[[Category: Trottet L]]
-
[[Category: Antagonist]]
+
[[Category: Witherington J]]
-
[[Category: Epigenetic reader]]
+
-
[[Category: Histone]]
+
-
[[Category: Inhibitor]]
+
-
[[Category: Transcription]]
+

Current revision

The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand

PDB ID 4bw2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4bw2"
Personal tools