4d9t

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==Rsk2 C-terminal Kinase Domain with inhibitor (E)-methyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylate==
==Rsk2 C-terminal Kinase Domain with inhibitor (E)-methyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylate==
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<StructureSection load='4d9t' size='340' side='right' caption='[[4d9t]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='4d9t' size='340' side='right'caption='[[4d9t]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4d9t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D9T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D9T FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4d9t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D9T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D9T FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0JG:METHYL+(2S)-3-{4-AMINO-7-[(1E)-3-HYDROXYPROP-1-EN-1-YL]-5-(4-METHYLPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-6-YL}-2-CYANOPROPANOATE'>0JG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4d9u|4d9u]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0JG:METHYL+(2S)-3-{4-AMINO-7-[(1E)-3-HYDROXYPROP-1-EN-1-YL]-5-(4-METHYLPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-6-YL}-2-CYANOPROPANOATE'>0JG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ISPK1, MAPKAPK1B, RPS6KA3, RSK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d9t OCA], [https://pdbe.org/4d9t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d9t RCSB], [https://www.ebi.ac.uk/pdbsum/4d9t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d9t ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d9t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d9t RCSB], [http://www.ebi.ac.uk/pdbsum/4d9t PDBsum]</span></td></tr>
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</table>
</table>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4d9t" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Ribosomal protein S6 kinase|Ribosomal protein S6 kinase]]
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*[[Ribosomal protein S6 kinase 3D structures|Ribosomal protein S6 kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Cohen, M S]]
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[[Category: Cohen MS]]
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[[Category: Duda, K]]
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[[Category: Duda K]]
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[[Category: Frodin, M]]
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[[Category: Frodin M]]
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[[Category: Krishnan, S]]
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[[Category: Krishnan S]]
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[[Category: Maglathlin, R L]]
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[[Category: Maglathlin RL]]
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[[Category: McFarland, J M]]
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[[Category: McFarland JM]]
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[[Category: Miller, R M]]
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[[Category: Miller RM]]
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[[Category: Pufall, M A]]
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[[Category: Pufall MA]]
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[[Category: Serafimova, I M]]
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[[Category: Serafimova IM]]
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[[Category: Taunton, J]]
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[[Category: Taunton J]]
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[[Category: Inhibitor]]
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[[Category: Kinase]]
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[[Category: Migration]]
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[[Category: Phosphorylation]]
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[[Category: Reversible]]
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[[Category: Thiol]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Rsk2 C-terminal Kinase Domain with inhibitor (E)-methyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylate

PDB ID 4d9t

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