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4ga6

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==Crystal structure of AMP phosphorylase C-terminal deletion mutant in complex with substrates==
==Crystal structure of AMP phosphorylase C-terminal deletion mutant in complex with substrates==
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<StructureSection load='4ga6' size='340' side='right' caption='[[4ga6]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
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<StructureSection load='4ga6' size='340' side='right'caption='[[4ga6]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ga6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_kodakaraensis_(strain_kod1) Pyrococcus kodakaraensis (strain kod1)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GA6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ga6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermococcus_kodakarensis_KOD1 Thermococcus kodakarensis KOD1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GA6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ga4|4ga4]], [[4ga5|4ga5]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">deoA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=69014 Pyrococcus kodakaraensis (strain KOD1)])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ga6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ga6 OCA], [https://pdbe.org/4ga6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ga6 RCSB], [https://www.ebi.ac.uk/pdbsum/4ga6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ga6 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_phosphorylase Thymidine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.4 2.4.2.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ga6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ga6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ga6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ga6 PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AMPPA_THEKO AMPPA_THEKO] Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP, dCMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.<ref>PMID:17303759</ref> <ref>PMID:23065974</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4ga6" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Thymidine phosphorylase]]
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[[Category: Large Structures]]
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[[Category: Aono, R]]
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[[Category: Thermococcus kodakarensis KOD1]]
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[[Category: Atomi, H]]
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[[Category: Aono R]]
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[[Category: Imanaka, T]]
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[[Category: Atomi H]]
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[[Category: Miki, K]]
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[[Category: Imanaka T]]
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[[Category: Nakamura, A]]
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[[Category: Miki K]]
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[[Category: Nishitani, Y]]
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[[Category: Nakamura A]]
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[[Category: Sato, T]]
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[[Category: Nishitani Y]]
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[[Category: Phosphorolysis]]
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[[Category: Sato T]]
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[[Category: Transferase]]
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Current revision

Crystal structure of AMP phosphorylase C-terminal deletion mutant in complex with substrates

PDB ID 4ga6

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