4b8w
From Proteopedia
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==Crystal structure of human GDP-L-fucose synthase with bound NADP and GDP, tetragonal crystal form== | ==Crystal structure of human GDP-L-fucose synthase with bound NADP and GDP, tetragonal crystal form== | ||
| - | <StructureSection load='4b8w' size='340' side='right' caption='[[4b8w]], [[Resolution|resolution]] 2.75Å' scene=''> | + | <StructureSection load='4b8w' size='340' side='right'caption='[[4b8w]], [[Resolution|resolution]] 2.75Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4b8w]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4b8w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B8W FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b8w OCA], [https://pdbe.org/4b8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b8w RCSB], [https://www.ebi.ac.uk/pdbsum/4b8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b8w ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FCL_HUMAN FCL_HUMAN] Two step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: GDP-L-fucose synthase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: Bountra | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bunkoczi | + | [[Category: Bountra C]] |
| - | [[Category: Carpenter | + | [[Category: Bunkoczi G]] |
| - | [[Category: Chaikuat | + | [[Category: Carpenter E]] |
| - | + | [[Category: Chaikuat A]] | |
| - | [[Category: Edwards | + | [[Category: Edwards A]] |
| - | [[Category: Kavanagh | + | [[Category: Kavanagh K]] |
| - | [[Category: Krojer | + | [[Category: Krojer T]] |
| - | [[Category: Oppermann | + | [[Category: Oppermann U]] |
| - | [[Category: Pike | + | [[Category: Pike A]] |
| - | [[Category: Rojkova | + | [[Category: Rojkova A]] |
| - | [[Category: Shafqat | + | [[Category: Shafqat N]] |
| - | [[Category: Vollmar | + | [[Category: Vollmar M]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
| - | [[Category: Yue | + | [[Category: Yue WW]] |
| - | [[Category: | + | [[Category: Von Delft F]] |
Current revision
Crystal structure of human GDP-L-fucose synthase with bound NADP and GDP, tetragonal crystal form
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Bunkoczi G | Carpenter E | Chaikuat A | Edwards A | Kavanagh K | Krojer T | Oppermann U | Pike A | Rojkova A | Shafqat N | Vollmar M | Weigelt J | Yue WW | Von Delft F
