4dzo
From Proteopedia
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==Structure of Human Mad1 C-terminal Domain Reveals Its Involvement in Kinetochore Targeting== | ==Structure of Human Mad1 C-terminal Domain Reveals Its Involvement in Kinetochore Targeting== | ||
| - | <StructureSection load='4dzo' size='340' side='right' caption='[[4dzo]], [[Resolution|resolution]] 1.76Å' scene=''> | + | <StructureSection load='4dzo' size='340' side='right'caption='[[4dzo]], [[Resolution|resolution]] 1.76Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4dzo]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4dzo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DZO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DZO FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.76Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dzo OCA], [https://pdbe.org/4dzo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dzo RCSB], [https://www.ebi.ac.uk/pdbsum/4dzo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dzo ProSAT]</span></td></tr> |
</table> | </table> | ||
| - | == Disease == | ||
| - | [[http://www.uniprot.org/uniprot/MD1L1_HUMAN MD1L1_HUMAN]] Defects in MAD1L1 are involved in the development and/or progression of various types of cancer. | ||
| - | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/MD1L1_HUMAN MD1L1_HUMAN]] Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.<ref>PMID:10049595</ref> <ref>PMID:12837246</ref> <ref>PMID:20133940</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4dzo" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Luo X]] |
| - | [[Category: | + | [[Category: Sun H]] |
| - | [[Category: | + | [[Category: Tomchick DR]] |
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Current revision
Structure of Human Mad1 C-terminal Domain Reveals Its Involvement in Kinetochore Targeting
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