4dd8

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==ADAM-8 metalloproteinase domain with bound batimastat==
==ADAM-8 metalloproteinase domain with bound batimastat==
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<StructureSection load='4dd8' size='340' side='right' caption='[[4dd8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4dd8' size='340' side='right'caption='[[4dd8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4dd8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DD8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DD8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4dd8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DD8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BAT:4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE'>BAT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADAM8, MS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BAT:4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE'>BAT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dd8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dd8 RCSB], [http://www.ebi.ac.uk/pdbsum/4dd8 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dd8 OCA], [https://pdbe.org/4dd8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dd8 RCSB], [https://www.ebi.ac.uk/pdbsum/4dd8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dd8 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ADAM8_HUMAN ADAM8_HUMAN] Possible involvement in extravasation of leukocytes.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4dd8" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[A Disintegrin And Metalloproteinase 3D structures|A Disintegrin And Metalloproteinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Caspers, N]]
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[[Category: Large Structures]]
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[[Category: Chrencik, J E]]
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[[Category: Caspers N]]
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[[Category: Day, J E]]
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[[Category: Chrencik JE]]
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[[Category: Fischer, D H]]
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[[Category: Day JE]]
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[[Category: Hall, T]]
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[[Category: Fischer DH]]
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[[Category: Kiefer, J R]]
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[[Category: Hall T]]
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[[Category: Krahn, J M]]
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[[Category: Kiefer JR]]
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[[Category: Moon, A F]]
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[[Category: Krahn JM]]
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[[Category: Pauley, A M]]
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[[Category: Moon AF]]
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[[Category: Pegg, L E]]
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[[Category: Pauley AM]]
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[[Category: Shieh, H S]]
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[[Category: Pegg LE]]
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[[Category: Tomasselli, A G]]
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[[Category: Shieh HS]]
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[[Category: Williams, J M]]
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[[Category: Tomasselli AG]]
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[[Category: Zack, M D]]
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[[Category: Williams JM]]
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[[Category: Aberrant neural cell signaling]]
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[[Category: Zack MD]]
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[[Category: Allergic asthma]]
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[[Category: Alpha/beta motif]]
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[[Category: Arthritis]]
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[[Category: Batimastat]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Inflammation]]
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[[Category: Metalloproteinase]]
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[[Category: Tumorigenesis]]
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Current revision

ADAM-8 metalloproteinase domain with bound batimastat

PDB ID 4dd8

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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