4po6
From Proteopedia
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==Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide== | ==Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide== | ||
| - | <StructureSection load='4po6' size='340' side='right' caption='[[4po6]], [[Resolution|resolution]] 1.99Å' scene=''> | + | <StructureSection load='4po6' size='340' side='right'caption='[[4po6]], [[Resolution|resolution]] 1.99Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4po6]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4po6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PO6 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4po6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4po6 OCA], [https://pdbe.org/4po6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4po6 RCSB], [https://www.ebi.ac.uk/pdbsum/4po6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4po6 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[https://omim.org/entry/611521 611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref> |
==See Also== | ==See Also== | ||
| - | *[[Tyrosine kinase|Tyrosine kinase]] | + | *[[Interferon receptor 3D structures|Interferon receptor 3D structures]] |
| + | *[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Lupardus | + | [[Category: Lupardus PJ]] |
| - | [[Category: Wallweber | + | [[Category: Wallweber HJA]] |
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Current revision
Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide
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