4lzx

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==Complex of IQCG and Ca2+-free CaM==
==Complex of IQCG and Ca2+-free CaM==
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<StructureSection load='4lzx' size='340' side='right' caption='[[4lzx]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='4lzx' size='340' side='right'caption='[[4lzx]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4lzx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LZX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LZX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4lzx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LZX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4m1l|4m1l]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lzx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lzx RCSB], [http://www.ebi.ac.uk/pdbsum/4lzx PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lzx OCA], [https://pdbe.org/4lzx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lzx RCSB], [https://www.ebi.ac.uk/pdbsum/4lzx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lzx ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
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== Function ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
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==See Also==
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chen, L T]]
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[[Category: Homo sapiens]]
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[[Category: Chen, S]]
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[[Category: Large Structures]]
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[[Category: Chen, S J]]
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[[Category: Chen LT]]
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[[Category: Chen, Z]]
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[[Category: Chen S]]
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[[Category: Liang, W X]]
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[[Category: Chen SJ]]
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[[Category: Calcium signalling]]
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[[Category: Chen Z]]
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[[Category: Ef hand domain]]
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[[Category: Liang WX]]
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[[Category: Iq domain]]
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[[Category: Metal binding protein]]
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[[Category: Protein complex]]
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Current revision

Complex of IQCG and Ca2+-free CaM

PDB ID 4lzx

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