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2hd4

From Proteopedia

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[[Image:2hd4.gif|left|200px]]
 
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{{Structure
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==Crystal structure of proteinase K inhibited by a lactoferrin octapeptide Gly-Asp-Glu-Gln-Gly-Glu-Asn-Lys at 2.15 A resolution==
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|PDB= 2hd4 |SIZE=350|CAPTION= <scene name='initialview01'>2hd4</scene>, resolution 2.15&Aring;
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<StructureSection load='2hd4' size='340' side='right'caption='[[2hd4]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=ACY:ACETIC ACID'>ACY</scene>
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<table><tr><td colspan='2'>[[2hd4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Parengyodontium_album Parengyodontium album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HD4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HD4 FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Peptidase_K Peptidase K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.64 3.4.21.64]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hd4 OCA], [https://pdbe.org/2hd4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hd4 RCSB], [https://www.ebi.ac.uk/pdbsum/2hd4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hd4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRTK_PARAQ PRTK_PARAQ] Hydrolyzes keratin at aromatic and hydrophobic residues.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hd/2hd4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hd4 ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of proteinase K inhibited by a lactoferrin octapeptide Gly-Asp-Glu-Gln-Gly-Glu-Asn-Lys at 2.15 A resolution'''
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==See Also==
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*[[Proteinase 3D structures|Proteinase 3D structures]]
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__TOC__
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==Disease==
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</StructureSection>
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Known disease associated with this structure: Deafness, autosomal dominant 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602121 602121]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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==About this Structure==
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[[Category: Parengyodontium album]]
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2HD4 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Engyodontium_album Engyodontium album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HD4 OCA].
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[[Category: Kaur P]]
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[[Category: Engyodontium album]]
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[[Category: Prem Kumar R]]
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[[Category: Peptidase K]]
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[[Category: Sharma S]]
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[[Category: Protein complex]]
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[[Category: Singh AK]]
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[[Category: Kaur, P.]]
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[[Category: Singh N]]
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[[Category: Kumar, R Prem.]]
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[[Category: Singh TP]]
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[[Category: Sharma, S.]]
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[[Category: Singh, A K.]]
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[[Category: Singh, N.]]
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[[Category: Singh, T P.]]
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[[Category: ACY]]
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[[Category: CA]]
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[[Category: complex]]
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[[Category: lactoferrin fragment]]
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[[Category: peptide complex]]
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[[Category: proteinase k]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:15:32 2008''
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Current revision

Crystal structure of proteinase K inhibited by a lactoferrin octapeptide Gly-Asp-Glu-Gln-Gly-Glu-Asn-Lys at 2.15 A resolution

PDB ID 2hd4

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