4m89

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==Crystal Structure of Enoyl-Acyl Carrier Protein Reductase (FabI) from Neisseria meningitidis in complex with NAD+ and Triclosan==
==Crystal Structure of Enoyl-Acyl Carrier Protein Reductase (FabI) from Neisseria meningitidis in complex with NAD+ and Triclosan==
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<StructureSection load='4m89' size='340' side='right' caption='[[4m89]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='4m89' size='340' side='right'caption='[[4m89]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4m89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis_fam18 Neisseria meningitidis fam18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M89 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4m89]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis_FAM18 Neisseria meningitidis FAM18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M89 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4m86|4m86]], [[4m87|4m87]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fabI, NMC1834 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272831 Neisseria meningitidis FAM18])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m89 OCA], [https://pdbe.org/4m89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m89 RCSB], [https://www.ebi.ac.uk/pdbsum/4m89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m89 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m89 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m89 RCSB], [http://www.ebi.ac.uk/pdbsum/4m89 PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A1KVU8_NEIMF A1KVU8_NEIMF]
==See Also==
==See Also==
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*[[Enoyl-Acyl-Carrier Protein Reductase|Enoyl-Acyl-Carrier Protein Reductase]]
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*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Neisseria meningitidis fam18]]
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[[Category: Large Structures]]
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[[Category: Forwood, J K]]
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[[Category: Neisseria meningitidis FAM18]]
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[[Category: Nanson, J D]]
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[[Category: Forwood JK]]
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[[Category: Acp]]
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[[Category: Nanson JD]]
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[[Category: Acyl carrier protein]]
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[[Category: Enoyl]]
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[[Category: Inhibitor]]
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[[Category: Nad]]
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[[Category: Neisseria]]
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[[Category: Oxidoreductase-antibiotic complex]]
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[[Category: Reductase]]
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[[Category: Rossmann fold]]
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[[Category: Triclosan]]
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Current revision

Crystal Structure of Enoyl-Acyl Carrier Protein Reductase (FabI) from Neisseria meningitidis in complex with NAD+ and Triclosan

PDB ID 4m89

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