This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2hgz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:32, 14 February 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2hgz.jpg|left|200px]]
 
-
{{Structure
+
==Crystal structure of a p-benzoyl-L-phenylalanyl-tRNA synthetase==
-
|PDB= 2hgz |SIZE=350|CAPTION= <scene name='initialview01'>2hgz</scene>, resolution 2.50&Aring;
+
<StructureSection load='2hgz' size='340' side='right'caption='[[2hgz]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-
|SITE= <scene name='pdbsite=AC1:Pbf+Binding+Site+For+Residue+A+308'>AC1</scene>
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=PBF:PARA-(BENZOYL)-PHENYLALANINE'>PBF</scene>
+
<table><tr><td colspan='2'>[[2hgz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HGZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HGZ FirstGlance]. <br>
-
|ACTIVITY= [http://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
|GENE= tyrS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PBF:PARA-(BENZOYL)-PHENYLALANINE'>PBF</scene></td></tr>
-
}}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hgz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hgz OCA], [https://pdbe.org/2hgz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hgz RCSB], [https://www.ebi.ac.uk/pdbsum/2hgz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hgz ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SYY_METJA SYY_METJA] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).<ref>PMID:10585437</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hg/2hgz_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hgz ConSurf].
 +
<div style="clear:both"></div>
-
'''Crystal structure of a p-benzoyl-L-phenylalanyl-tRNA synthetase'''
+
==See Also==
-
 
+
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
2HGZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HGZ OCA].
+
__TOC__
-
 
+
</StructureSection>
-
==Reference==
+
[[Category: Large Structures]]
-
Structural basis for the recognition of para-benzoyl-L-phenylalanine by evolved aminoacyl-tRNA synthetases., Liu W, Alfonta L, Mack AV, Schultz PG, Angew Chem Int Ed Engl. 2007;46(32):6073-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17628477 17628477]
+
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
-
[[Category: Single protein]]
+
[[Category: Alfonta L]]
-
[[Category: Tyrosine--tRNA ligase]]
+
[[Category: Liu W]]
-
[[Category: Alfonta, L.]]
+
[[Category: Mack AV]]
-
[[Category: Liu, W.]]
+
[[Category: Schultz PG]]
-
[[Category: Mack, A V.]]
+
-
[[Category: Schultz, P G.]]
+
-
[[Category: PBF]]
+
-
[[Category: aminoacyl-trna synthetase]]
+
-
[[Category: ligase]]
+
-
[[Category: p-benzoyl-l-phenylalanine]]
+
-
[[Category: unnatural amino acid]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:16:59 2008''
+

Current revision

Crystal structure of a p-benzoyl-L-phenylalanyl-tRNA synthetase

PDB ID 2hgz

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hgz"
Personal tools