This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4mee

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:26, 1 March 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal structure of the transport unit of the autotransporter AIDA-I from Escherichia coli==
==Crystal structure of the transport unit of the autotransporter AIDA-I from Escherichia coli==
-
<StructureSection load='4mee' size='340' side='right' caption='[[4mee]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
+
<StructureSection load='4mee' size='340' side='right'caption='[[4mee]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4mee]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MEE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MEE FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4mee]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MEE FirstGlance]. <br>
-
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mee OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mee RCSB], [http://www.ebi.ac.uk/pdbsum/4mee PDBsum]</span></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mee OCA], [https://pdbe.org/4mee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mee RCSB], [https://www.ebi.ac.uk/pdbsum/4mee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mee ProSAT]</span></td></tr>
</table>
</table>
-
<div style="background-color:#fffaf0;">
+
== Function ==
-
== Publication Abstract from PubMed ==
+
[https://www.uniprot.org/uniprot/AIDA_ECOLX AIDA_ECOLX] Potent bacterial adhesin that mediates bacterial attachment to a broad variety of human and other mammalian cells. AIDA possesses additional virulence properties, as it is capable of mediating bacterial autoaggregation via intercellular self-recognition and it is a highly efficient initiator of biofilm formation.<ref>PMID:15547278</ref>
-
Several serious gastrointestinal diseases, which are widespread all over the world, are caused by enteropathogenic Escherichia coli. The monomeric autotransporter AIDA-I (adhesin involved in diffuse adherence) represents an important virulence factor of these strains and is involved in adhesion, biofilm formation, aggregation and invasion into host cells. Here, we present the crystal structure of the transport unit of AIDA-I at 3.0A resolution, which forms a 12-stranded beta-barrel harboring the linker domain in its pore. Mutagenesis studies of the C-terminal amino acid demonstrated the great impact of this terminal residue on membrane integration of AIDA-I and passenger translocation.
+
-
 
+
-
Crystal structure of the transport unit of the autotransporter adhesin involved in diffuse adherence from Escherichia coli.,Gawarzewski I, DiMaio F, Winterer E, Tschapek B, Smits SH, Jose J, Schmitt L J Struct Biol. 2014 May 16. pii: S1047-8477(14)00109-9. doi:, 10.1016/j.jsb.2014.05.003. PMID:24841284<ref>PMID:24841284</ref>
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
==See Also==
-
</div>
+
*[[Adhesin 3D structures|Adhesin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Gawarzewski, I]]
+
[[Category: Escherichia coli]]
-
[[Category: Hoeppner, A]]
+
[[Category: Large Structures]]
-
[[Category: Jose, J]]
+
[[Category: Gawarzewski I]]
-
[[Category: Schmitt, L]]
+
[[Category: Hoeppner A]]
-
[[Category: Smits, S H]]
+
[[Category: Jose J]]
-
[[Category: Tschapek, B]]
+
[[Category: Schmitt L]]
-
[[Category: Autotransporter]]
+
[[Category: Smits SH]]
-
[[Category: Beta barrel]]
+
[[Category: Tschapek B]]
-
[[Category: Outer membrane protein]]
+
-
[[Category: Protein binding]]
+

Current revision

Crystal structure of the transport unit of the autotransporter AIDA-I from Escherichia coli

PDB ID 4mee

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4mee"
Personal tools