4kqx

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==Mutant Slackia exigua KARI DDV in complex with NAD and an inhibitor==
==Mutant Slackia exigua KARI DDV in complex with NAD and an inhibitor==
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<StructureSection load='4kqx' size='340' side='right' caption='[[4kqx]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='4kqx' size='340' side='right'caption='[[4kqx]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4kqx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Slackia_exigua_atcc_700122 Slackia exigua atcc 700122]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KQX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4kqx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Slackia_exigua_ATCC_700122 Slackia exigua ATCC 700122]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KQX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIO:N-HYDROXY-N-ISOPROPYLOXAMIC+ACID'>HIO</scene>, <scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kqw|4kqw]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HIO:N-HYDROXY-N-ISOPROPYLOXAMIC+ACID'>HIO</scene>, <scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ilvC, HMPREF0762_00954 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=649764 Slackia exigua ATCC 700122])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kqx OCA], [https://pdbe.org/4kqx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kqx RCSB], [https://www.ebi.ac.uk/pdbsum/4kqx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kqx ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ketol-acid_reductoisomerase Ketol-acid reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.86 1.1.1.86] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kqx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kqx RCSB], [http://www.ebi.ac.uk/pdbsum/4kqx PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ILVC_SLAES ILVC_SLAES] Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.[HAMAP-Rule:MF_00435]<ref>PMID:23776225</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4kqx" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ketol-acid reductoisomerase 3D structures|Ketol-acid reductoisomerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ketol-acid reductoisomerase]]
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[[Category: Large Structures]]
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[[Category: Slackia exigua atcc 700122]]
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[[Category: Slackia exigua ATCC 700122]]
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[[Category: Arnold, F H]]
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[[Category: Arnold FH]]
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[[Category: Brinkmann-Chen, S]]
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[[Category: Brinkmann-Chen S]]
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[[Category: Brustad, E M]]
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[[Category: Brustad EM]]
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[[Category: Cahn, J K.B]]
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[[Category: Cahn JKB]]
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[[Category: Flock, T]]
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[[Category: Flock T]]
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[[Category: Mcintosh, J A]]
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[[Category: Mcintosh JA]]
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[[Category: Meinhold, P]]
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[[Category: Meinhold P]]
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[[Category: Snow, C D]]
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[[Category: Snow CD]]
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[[Category: Zhang, L]]
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[[Category: Zhang L]]
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[[Category: Acetohydroxyacid isomeroreductase]]
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[[Category: Cofactor switch]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Rossmann fold]]
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Current revision

Mutant Slackia exigua KARI DDV in complex with NAD and an inhibitor

PDB ID 4kqx

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