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4cri

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==Crystal Structure of 53BP1 tandem tudor domains in complex with methylated K810 Rb peptide==
==Crystal Structure of 53BP1 tandem tudor domains in complex with methylated K810 Rb peptide==
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<StructureSection load='4cri' size='340' side='right' caption='[[4cri]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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<StructureSection load='4cri' size='340' side='right'caption='[[4cri]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4cri]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CRI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4cri]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CRI FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cri OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cri RCSB], [http://www.ebi.ac.uk/pdbsum/4cri PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cri OCA], [https://pdbe.org/4cri PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cri RCSB], [https://www.ebi.ac.uk/pdbsum/4cri PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cri ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
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[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>
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[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4cri" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Homo sapiens]]
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[[Category: Bountra, C]]
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[[Category: Large Structures]]
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[[Category: Carr, S]]
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[[Category: Arrowsmith CH]]
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[[Category: Crawley, L]]
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[[Category: Bountra C]]
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[[Category: Delft, F von]]
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[[Category: Carr S]]
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[[Category: Edwards, A]]
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[[Category: Crawley L]]
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[[Category: Fedorov, O]]
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[[Category: Edwards A]]
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[[Category: Gileadi, C]]
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[[Category: Fedorov O]]
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[[Category: Johansson, C]]
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[[Category: Gileadi C]]
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[[Category: Krojer, T]]
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[[Category: Johansson C]]
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[[Category: Oppermann, U]]
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[[Category: Krojer T]]
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[[Category: Thangue, N B.La]]
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[[Category: La Thangue NB]]
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[[Category: Vollmar, M]]
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[[Category: Oppermann U]]
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[[Category: Peptide binding protein]]
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[[Category: Vollmar M]]
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[[Category: Tumour suppressor prb]]
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[[Category: Von Delft F]]

Current revision

Crystal Structure of 53BP1 tandem tudor domains in complex with methylated K810 Rb peptide

PDB ID 4cri

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