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4okz

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==Selinadiene Synthase in complex with dihydrofarnesyl pyrophosphate==
==Selinadiene Synthase in complex with dihydrofarnesyl pyrophosphate==
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<StructureSection load='4okz' size='340' side='right' caption='[[4okz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='4okz' size='340' side='right'caption='[[4okz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4okz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OKZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4okz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_pristinaespiralis_ATCC_25486 Streptomyces pristinaespiralis ATCC 25486]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OKZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3E9:(3S,6E)-3,7,11-TRIMETHYLDODECA-6,10-DIEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>3E9</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ps1|1ps1]], [[4mc0|4mc0]], [[4mc3|4mc3]], [[4okm|4okm]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3E9:(3S,6E)-3,7,11-TRIMETHYLDODECA-6,10-DIEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>3E9</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okz OCA], [https://pdbe.org/4okz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4okz RCSB], [https://www.ebi.ac.uk/pdbsum/4okz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4okz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4okz RCSB], [http://www.ebi.ac.uk/pdbsum/4okz PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SEDS_STRE2 SEDS_STRE2] Catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) to yield the bicyclic sesquiterpene selina-4(15),7(11)-diene via a 1,10-cyclization, which requires the abstraction of the pyrophosphate from FPP leading to a (E,E)-germacradienyl cation (PubMed:23307484, PubMed:24890698). The only accepted substrate is (2E,6E)-farnesyl diphosphate (FPP) (PubMed:23307484, PubMed:24890698).<ref>PMID:23307484</ref> <ref>PMID:24890698</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4okz" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Squalene synthase]]
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[[Category: Large Structures]]
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[[Category: Baer, P]]
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[[Category: Streptomyces pristinaespiralis ATCC 25486]]
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[[Category: Citron, C A]]
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[[Category: Baer P]]
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[[Category: Dickschat, J S]]
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[[Category: Citron CA]]
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[[Category: Fischer, K]]
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[[Category: Dickschat JS]]
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[[Category: Groll, M]]
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[[Category: Fischer K]]
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[[Category: Klapschinski, T]]
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[[Category: Groll M]]
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[[Category: Rabe, P]]
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[[Category: Klapschinski T]]
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[[Category: Closed conformation]]
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[[Category: Rabe P]]
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[[Category: Cyclase]]
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[[Category: Dihydrofarnesyl pyrophosphate]]
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[[Category: Induced fit]]
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[[Category: Pyrophosphate sensor]]
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[[Category: Sesquiterpene]]
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[[Category: Terpenoid]]
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[[Category: Transferase]]
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Current revision

Selinadiene Synthase in complex with dihydrofarnesyl pyrophosphate

PDB ID 4okz

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