This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2hma
From Proteopedia
(Difference between revisions)
| (12 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:2hma.gif|left|200px]] | ||
| - | + | ==The Crystal Structure of tRNA (5-Methylaminomethyl-2-Thiouridylate)-Methyltransferase TrmU from Streptococcus pneumoniae== | |
| - | + | <StructureSection load='2hma' size='340' side='right'caption='[[2hma]], [[Resolution|resolution]] 2.41Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | | | + | <table><tr><td colspan='2'>[[2hma]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HMA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HMA FirstGlance]. <br> |
| - | | | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr> |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">trmU ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/tRNA_(5-methylaminomethyl-2-thiouridylate)-methyltransferase tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.61 2.1.1.61] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hma FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hma OCA], [https://pdbe.org/2hma PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hma RCSB], [https://www.ebi.ac.uk/pdbsum/2hma PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hma ProSAT], [https://www.topsan.org/Proteins/MCSG/2hma TOPSAN]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | == | + | [[https://www.uniprot.org/uniprot/MNMA_STRPN MNMA_STRPN]] Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | + | Check<jmol> | |
| - | [[Category: | + | <jmolCheckbox> |
| - | [[Category: Abdullah, J | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hm/2hma_consurf.spt"</scriptWhenChecked> |
| - | [[Category: Joachimiak, A | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [[Category: Kim, Y | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | [[Category: | + | </jmolCheckbox> |
| - | [[Category: Zhou, M | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hma ConSurf]. |
| - | [[Category: | + | <div style="clear:both"></div> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Abdullah, J]] |
| - | [[Category: | + | [[Category: Joachimiak, A]] |
| - | + | [[Category: Kim, Y]] | |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | + | [[Category: Zhou, M]] | |
| - | + | [[Category: Alpha-beta]] | |
| - | + | [[Category: Beta barrel]] | |
| + | [[Category: Mcsg]] | ||
| + | [[Category: PSI, Protein structure initiative]] | ||
| + | [[Category: Transferase]] | ||
Current revision
The Crystal Structure of tRNA (5-Methylaminomethyl-2-Thiouridylate)-Methyltransferase TrmU from Streptococcus pneumoniae
| |||||||||||
