3n5n

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==Crystal structure analysis of the catalytic domain and interdomain connector of human MutY homologue==
==Crystal structure analysis of the catalytic domain and interdomain connector of human MutY homologue==
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<StructureSection load='3n5n' size='340' side='right' caption='[[3n5n]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='3n5n' size='340' side='right'caption='[[3n5n]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3n5n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N5N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3n5n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N5N FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MUTYH, MYH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n5n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n5n RCSB], [http://www.ebi.ac.uk/pdbsum/3n5n PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n5n OCA], [https://pdbe.org/3n5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n5n RCSB], [https://www.ebi.ac.uk/pdbsum/3n5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n5n ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/MUTYH_HUMAN MUTYH_HUMAN]] Defects in MUTYH are a cause of familial adenomatous polyposis type 2 (FAP2) [MIM:[http://omim.org/entry/608456 608456]]. A condition characterized by the development of multiple colorectal adenomatous polyps, benign neoplasms derived from glandular epithelium. Some affected individuals may develop colorectal carcinoma.<ref>PMID:11818965</ref> <ref>PMID:12853198</ref> <ref>PMID:12606733</ref> <ref>PMID:15366000</ref> <ref>PMID:18091433</ref> <ref>PMID:19953527</ref> Defects in MUTYH are a cause of gastric cancer (GASC) [MIM:[http://omim.org/entry/613659 613659]]. A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.<ref>PMID:15273732</ref>
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[https://www.uniprot.org/uniprot/MUTYH_HUMAN MUTYH_HUMAN] Defects in MUTYH are a cause of familial adenomatous polyposis type 2 (FAP2) [MIM:[https://omim.org/entry/608456 608456]. A condition characterized by the development of multiple colorectal adenomatous polyps, benign neoplasms derived from glandular epithelium. Some affected individuals may develop colorectal carcinoma.<ref>PMID:11818965</ref> <ref>PMID:12853198</ref> <ref>PMID:12606733</ref> <ref>PMID:15366000</ref> <ref>PMID:18091433</ref> <ref>PMID:19953527</ref> Defects in MUTYH are a cause of gastric cancer (GASC) [MIM:[https://omim.org/entry/613659 613659]. A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.<ref>PMID:15273732</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MUTYH_HUMAN MUTYH_HUMAN]] Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.<ref>PMID:10684930</ref>
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[https://www.uniprot.org/uniprot/MUTYH_HUMAN MUTYH_HUMAN] Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.<ref>PMID:10684930</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3n5n" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[DNA glycosylase|DNA glycosylase]]
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*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Luncsford, P J]]
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[[Category: Large Structures]]
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[[Category: Toth, E A]]
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[[Category: Luncsford PJ]]
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[[Category: Alpha-helice]]
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[[Category: Toth EA]]
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[[Category: Helix-hairpin-helix motif]]
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[[Category: Hydrolase]]
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[[Category: Iron-sulfur cluster]]
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Current revision

Crystal structure analysis of the catalytic domain and interdomain connector of human MutY homologue

PDB ID 3n5n

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