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| - | [[Image:2huy.gif|left|200px]] | + | #REDIRECT [[3c7i]] This PDB entry is obsolete and replaced by 3c7i |
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| - | {{Structure
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| - | |PDB= 2huy |SIZE=350|CAPTION= <scene name='initialview01'>2huy</scene>, resolution 1.700Å
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| - | |SITE=
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| - | |LIGAND= <scene name='pdbligand=YVN:N-({(1R,2R,3S)-2-[(METHYLAMINO)CARBONYL]-3-[4-(PHOSPHONOOXY)PHENYL]CYCLOPROPYL}CARBONYL)-L-VALYL-L-ASPARTAMIDE'>YVN</scene> and <scene name='pdbligand=FMT:FORMIC ACID'>FMT</scene>
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| - | |ACTIVITY=
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| - | |GENE= GRB2, ASH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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| - | }}
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| - | '''X-ray crystal structure of the complex between the Grb2-SH2 domain and a flexible ligand, fpYVN.'''
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| - | ==Disease==
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| - | Known diseases associated with this structure: Central hypoventilation syndrome, congenital OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=100790 100790]], Haddad syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=100790 100790]]
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| - | ==About this Structure==
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| - | 2HUY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HUY OCA].
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| - | ==Reference==
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| - | Ligand preorganization may be accompanied by entropic penalties in protein-ligand interactions., Benfield AP, Teresk MG, Plake HR, DeLorbe JE, Millspaugh LE, Martin SF, Angew Chem Int Ed Engl. 2006 Oct 20;45(41):6830-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17001728 17001728]
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| - | [[Category: Homo sapiens]]
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| - | [[Category: Single protein]]
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| - | [[Category: Benfield, A P.]]
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| - | [[Category: Martin, S F.]]
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| - | [[Category: FMT]]
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| - | [[Category: YVN]]
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| - | [[Category: constrained]]
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| - | [[Category: entropy]]
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| - | [[Category: flexible]]
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| - | [[Category: grb2-sh2]]
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| - | [[Category: ligand preorganization]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:21:54 2008''
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