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2i7a

From Proteopedia

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[[Image:2i7a.gif|left|200px]]
 
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{{Structure
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==Domain IV of Human Calpain 13==
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|PDB= 2i7a |SIZE=350|CAPTION= <scene name='initialview01'>2i7a</scene>, resolution 1.80&Aring;
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<StructureSection load='2i7a' size='340' side='right'caption='[[2i7a]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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<table><tr><td colspan='2'>[[2i7a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I7A FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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|GENE= CAPN13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i7a OCA], [https://pdbe.org/2i7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i7a RCSB], [https://www.ebi.ac.uk/pdbsum/2i7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i7a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAN13_HUMAN CAN13_HUMAN] Probable non-lysosomal thiol-protease.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i7/2i7a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i7a ConSurf].
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<div style="clear:both"></div>
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'''Domain IV of Human Calpain 13'''
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==See Also==
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*[[Calpain 3D structures|Calpain 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2I7A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7A OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev A]]
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[[Category: Butler-cole, C.]]
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[[Category: Butler-cole C]]
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[[Category: Davis, T L]]
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[[Category: Davis TL]]
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[[Category: Dhe-Paganon, S.]]
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[[Category: Dhe-Paganon S]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Jr., P J.Finerty.]]
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[[Category: Finerty Jr PJ]]
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[[Category: Newman, E M.]]
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[[Category: Newman EM]]
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[[Category: Ng, K.]]
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[[Category: Ng K]]
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[[Category: Ravulapalli, R.]]
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[[Category: Ravulapalli R]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Walker JR]]
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[[Category: Walker, J R.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: CA]]
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[[Category: GOL]]
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[[Category: SO4]]
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[[Category: calcium-dependent cytoplasmic cysteine proteinase]]
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[[Category: calpain]]
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[[Category: ef-hand]]
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[[Category: papain-like]]
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[[Category: sgc]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:26:17 2008''
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Current revision

Domain IV of Human Calpain 13

PDB ID 2i7a

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