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2i7p

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[[Image:2i7p.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of human PANK3 in complex with AcCoA==
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|PDB= 2i7p |SIZE=350|CAPTION= <scene name='initialview01'>2i7p</scene>, resolution 2.05&Aring;
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<StructureSection load='2i7p' size='340' side='right'caption='[[2i7p]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ACO:ACETYL COENZYME *A'>ACO</scene>
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<table><tr><td colspan='2'>[[2i7p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I7P FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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|GENE= PANK3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i7p OCA], [https://pdbe.org/2i7p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i7p RCSB], [https://www.ebi.ac.uk/pdbsum/2i7p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i7p ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PANK3_HUMAN PANK3_HUMAN] Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i7/2i7p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i7p ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of human PANK3 in complex with AcCoA'''
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==See Also==
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*[[Pantothenate kinase 3D structures|Pantothenate kinase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2I7P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7P OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Pantothenate kinase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Bochkarev A]]
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[[Category: Bochkarev, A.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Finerty P]]
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[[Category: Finerty, P.]]
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[[Category: Hong BS]]
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[[Category: Hong, B.]]
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[[Category: Loppnau P]]
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[[Category: Loppnau, P.]]
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[[Category: Park HW]]
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[[Category: Park, H.]]
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[[Category: Shen L]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sundstrom M]]
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[[Category: Shen, L.]]
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[[Category: Tempel W]]
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[[Category: Sundstrom, M.]]
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[[Category: Wang L]]
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[[Category: Tempel, W.]]
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[[Category: Weigelt J]]
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[[Category: Wang, L.]]
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[[Category: Weigelt, J.]]
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[[Category: ACO]]
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[[Category: pank]]
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[[Category: sgc]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:26:25 2008''
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Current revision

Crystal structure of human PANK3 in complex with AcCoA

PDB ID 2i7p

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