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1wz9

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==The 2.1 A structure of a tumour suppressing serpin==
==The 2.1 A structure of a tumour suppressing serpin==
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<StructureSection load='1wz9' size='340' side='right' caption='[[1wz9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='1wz9' size='340' side='right'caption='[[1wz9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1wz9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WZ9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1wz9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WZ9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xu8|1xu8]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wz9 OCA], [https://pdbe.org/1wz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wz9 RCSB], [https://www.ebi.ac.uk/pdbsum/1wz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wz9 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SERPINB5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wz9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wz9 RCSB], [http://www.ebi.ac.uk/pdbsum/1wz9 PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPB5_HUMAN SPB5_HUMAN] Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wz/1wz9_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wz/1wz9_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wz9 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1wz9" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Serpin|Serpin]]
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*[[Serpin 3D structures|Serpin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bashtannyk-Puhalovich, T A]]
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[[Category: Large Structures]]
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[[Category: Beddoe, T C]]
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[[Category: Bashtannyk-Puhalovich TA]]
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[[Category: Bird, P I]]
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[[Category: Beddoe TC]]
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[[Category: Bottomley, S P]]
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[[Category: Bird PI]]
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[[Category: Buckle, A M]]
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[[Category: Bottomley SP]]
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[[Category: Buzza, M]]
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[[Category: Buckle AM]]
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[[Category: Irving, J A]]
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[[Category: Buzza M]]
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[[Category: Kim, N]]
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[[Category: Irving JA]]
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[[Category: Law, R H]]
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[[Category: Kim N]]
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[[Category: Rossjohn, J]]
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[[Category: Law RH]]
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[[Category: Ruzyla, K]]
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[[Category: Rossjohn J]]
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[[Category: Whisstock, J C]]
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[[Category: Ruzyla K]]
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[[Category: Worrall, D M]]
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[[Category: Whisstock JC]]
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[[Category: Maspin]]
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[[Category: Worrall DM]]
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[[Category: Serpin]]
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[[Category: Serpinb5]]
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[[Category: Signaling protein]]
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[[Category: Tumor suppressor]]
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Current revision

The 2.1 A structure of a tumour suppressing serpin

PDB ID 1wz9

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