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1xhc

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==NADH oxidase /nitrite reductase from Pyrococcus furiosus Pfu-1140779-001==
==NADH oxidase /nitrite reductase from Pyrococcus furiosus Pfu-1140779-001==
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<StructureSection load='1xhc' size='340' side='right' caption='[[1xhc]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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<StructureSection load='1xhc' size='340' side='right'caption='[[1xhc]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1xhc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XHC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XHC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1xhc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XHC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XHC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xhc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xhc RCSB], [http://www.ebi.ac.uk/pdbsum/1xhc PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xhc OCA], [https://pdbe.org/1xhc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xhc RCSB], [https://www.ebi.ac.uk/pdbsum/1xhc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xhc ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NROR_PYRFU NROR_PYRFU] Catalyzes the NADH-dependent reduction of rubredoxin (Rd), a small iron-containing redox protein (PubMed:10464233, PubMed:11398485, PubMed:15746356). Can also reduce other electron carriers, including 2,6-dichlorophenol indophenol, benzyl viologen and menadione, but rubredoxin is the most efficient electron acceptor (PubMed:10464233, PubMed:11398485, PubMed:15746356). Does not reduce ferredoxin (PubMed:10464233). Shows comparable activity with NADPH and NADH as electron donors, but NADPH is probably the preferred physiological electron donor (PubMed:10464233, PubMed:11398485). Is probably part of an oxygen detoxification system that protects P.furiosus during exposure to oxygen (PubMed:15746356).<ref>PMID:10464233</ref> <ref>PMID:11398485</ref> <ref>PMID:15746356</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xh/1xhc_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xh/1xhc_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xhc ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pyrococcus furiosus]]
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[[Category: Large Structures]]
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[[Category: Adams, M W.W]]
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[[Category: Pyrococcus furiosus DSM 3638]]
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[[Category: Brereton, P S]]
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[[Category: Adams MWW]]
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[[Category: Chen, L]]
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[[Category: Arendall III WB]]
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[[Category: Horanyi, P]]
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[[Category: Brereton PS]]
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[[Category: II, F L.Poole]]
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[[Category: Chen L]]
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[[Category: III, W B.Arendall]]
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[[Category: Horanyi P]]
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[[Category: Izumi, M]]
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[[Category: Izumi M]]
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[[Category: Jenney, F E]]
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[[Category: Jenney Jr FE]]
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[[Category: Lee, D]]
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[[Category: Lee D]]
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[[Category: Liu, Z J]]
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[[Category: Liu Z-J]]
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[[Category: Richardson, D C]]
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[[Category: Poole II FL]]
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[[Category: Richardson, J S]]
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[[Category: Richardson DC]]
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[[Category: Rose, J P]]
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[[Category: Richardson JS]]
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[[Category: Structural genomic]]
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[[Category: Rose JP]]
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[[Category: Shah, A]]
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[[Category: Shah A]]
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[[Category: Shah, C]]
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[[Category: Shah C]]
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[[Category: Sugar, F J]]
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[[Category: Sugar FJ]]
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[[Category: Tempel, W]]
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[[Category: Tempel W]]
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[[Category: Wang, B C]]
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[[Category: Wang B-C]]
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[[Category: Weinberg, M V]]
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[[Category: Weinberg MV]]
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[[Category: Hyperthermophile]]
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[[Category: Nadh oxidase]]
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[[Category: Nitrite reductase]]
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[[Category: Oxidoreductase]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Secsg]]
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Current revision

NADH oxidase /nitrite reductase from Pyrococcus furiosus Pfu-1140779-001

PDB ID 1xhc

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