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2iii

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[[Image:2iii.gif|left|200px]]
 
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{{Structure
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==Crystal structure of the adenosylmethionine decarboxylase (aq_254) from aquifex aeolicus vf5==
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|PDB= 2iii |SIZE=350|CAPTION= <scene name='initialview01'>2iii</scene>, resolution 2.30&Aring;
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<StructureSection load='2iii' size='340' side='right'caption='[[2iii]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
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<table><tr><td colspan='2'>[[2iii]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus_VF5 Aquifex aeolicus VF5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2III OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2III FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Adenosylmethionine_decarboxylase Adenosylmethionine decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.50 4.1.1.50]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iii OCA], [https://pdbe.org/2iii PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iii RCSB], [https://www.ebi.ac.uk/pdbsum/2iii PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iii ProSAT], [https://www.topsan.org/Proteins/RSGI/2iii TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPEH_AQUAE SPEH_AQUAE] Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ii/2iii_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iii ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of the adenosylmethionine decarboxylase (aq_254) from aquifex aeolicus vf5'''
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==See Also==
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*[[SAM decarboxylase|SAM decarboxylase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2III is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2III OCA].
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[[Category: Aquifex aeolicus VF5]]
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[[Category: Adenosylmethionine decarboxylase]]
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[[Category: Large Structures]]
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[[Category: Aquifex aeolicus]]
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[[Category: Baba S]]
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[[Category: Single protein]]
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[[Category: Ebihara A]]
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[[Category: Baba, S.]]
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[[Category: Jeyakanthan J]]
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[[Category: Ebihara, A.]]
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[[Category: Kanaujia SP]]
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[[Category: Jeyakanthan, J.]]
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[[Category: Kuramitsu S]]
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[[Category: Kanaujia, S P.]]
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[[Category: Sekar K]]
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[[Category: Kuramitsu, S.]]
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[[Category: Shinkai A]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Shiro Y]]
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[[Category: Ranjani, C Vasuki.]]
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[[Category: Vasuki Ranjani C]]
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[[Category: Sekar, K.]]
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[[Category: Yokoyama S]]
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[[Category: Shinkai, A.]]
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[[Category: Shiro, Y.]]
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[[Category: Yokoyama, S.]]
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[[Category: CA]]
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[[Category: MG]]
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[[Category: lyase]]
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[[Category: national project on protein structural and functional analyse]]
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[[Category: nppsfa]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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[[Category: two-layer alpha beta-sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:30:00 2008''
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Current revision

Crystal structure of the adenosylmethionine decarboxylase (aq_254) from aquifex aeolicus vf5

PDB ID 2iii

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