2iks

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[[Image:2iks.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of N-terminal truncated DNA-binding transcriptional dual regulator from Escherichia coli K12==
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|PDB= 2iks |SIZE=350|CAPTION= <scene name='initialview01'>2iks</scene>, resolution 1.85&Aring;
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<StructureSection load='2iks' size='340' side='right'caption='[[2iks]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2iks]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IKS FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iks OCA], [https://pdbe.org/2iks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iks RCSB], [https://www.ebi.ac.uk/pdbsum/2iks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iks ProSAT], [https://www.topsan.org/Proteins/MCSG/2iks TOPSAN]</span></td></tr>
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</table>
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'''Crystal structure of N-terminal truncated DNA-binding transcriptional dual regulator from Escherichia coli K12'''
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== Function ==
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[https://www.uniprot.org/uniprot/CRA_ECOLI CRA_ECOLI] Global transcriptional regulator, which plays an important role in the regulation of carbon metabolism. Activates transcription of genes encoding biosynthetic and oxidative enzymes (involved in Krebs cycle, glyoxylate shunt and gluconeogenesis, such as ppsA and fbp). Represses genes involved in sugar catabolism, such as fruB, pfkA, pykF and adhE. Binds asymmetrically to the two half-sites of its operator.<ref>PMID:16115199</ref> <ref>PMID:8195118</ref> <ref>PMID:8230205</ref> <ref>PMID:8550429</ref> <ref>PMID:8577250</ref> <ref>PMID:8858581</ref> <ref>PMID:9084760</ref> <ref>PMID:9371462</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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2IKS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IKS OCA].
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Check<jmol>
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[[Category: Escherichia coli]]
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<jmolCheckbox>
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[[Category: Single protein]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ik/2iks_consurf.spt"</scriptWhenChecked>
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[[Category: Chang, C.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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[[Category: Edwards, A M.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Evdokimova, E.]]
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</jmolCheckbox>
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[[Category: Joachimiak, A.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iks ConSurf].
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[[Category: Kagan, O.]]
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<div style="clear:both"></div>
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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== References ==
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[[Category: Savchenko, A.]]
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<references/>
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[[Category: dna-binding transcriptional dual regulator]]
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__TOC__
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[[Category: escherichia coli k12]]
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</StructureSection>
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[[Category: mcsg]]
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[[Category: Escherichia coli K-12]]
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[[Category: midwest center for structural genomic]]
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[[Category: Large Structures]]
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[[Category: protein structure initiative]]
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[[Category: Chang C]]
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[[Category: psi-2]]
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[[Category: Edwards AM]]
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[[Category: structural genomic]]
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[[Category: Evdokimova E]]
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[[Category: Joachimiak A]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:30:48 2008''
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[[Category: Kagan O]]
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[[Category: Savchenko A]]

Current revision

Crystal structure of N-terminal truncated DNA-binding transcriptional dual regulator from Escherichia coli K12

PDB ID 2iks

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