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2ipx

From Proteopedia

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[[Image:2ipx.gif|left|200px]]
 
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{{Structure
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==Human Fibrillarin==
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|PDB= 2ipx |SIZE=350|CAPTION= <scene name='initialview01'>2ipx</scene>, resolution 1.82&Aring;
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<StructureSection load='2ipx' size='340' side='right'caption='[[2ipx]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=MTA:5'-DEOXY-5'-METHYLTHIOADENOSINE'>MTA</scene>
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<table><tr><td colspan='2'>[[2ipx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IPX FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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|GENE= FBL, FIB1, FLRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ipx OCA], [https://pdbe.org/2ipx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ipx RCSB], [https://www.ebi.ac.uk/pdbsum/2ipx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ipx ProSAT]</span></td></tr>
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</table>
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'''Human Fibrillarin'''
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== Function ==
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[https://www.uniprot.org/uniprot/FBRL_HUMAN FBRL_HUMAN] Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
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== Evolutionary Conservation ==
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==Disease==
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[[Image:Consurf_key_small.gif|200px|right]]
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Known disease associated with this structure: Synpolydactyly, 3/3 4, associated with metacarpal and metatarsal synostoses OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=135820 135820]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/2ipx_consurf.spt"</scriptWhenChecked>
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2IPX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPX OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ipx ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Loppnau, P.]]
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[[Category: Loppnau P]]
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[[Category: Min, J.]]
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[[Category: Min J]]
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[[Category: Plotnikov, A N.]]
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[[Category: Plotnikov AN]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Wu H]]
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[[Category: Wu, H.]]
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[[Category: Zeng H]]
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[[Category: Zeng, H.]]
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[[Category: CA]]
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[[Category: MTA]]
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[[Category: fbl]]
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[[Category: sgc]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:32:13 2008''
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Current revision

Human Fibrillarin

PDB ID 2ipx

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