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4tkf

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==Crystal Structure of human Tankyrase 2 in complex with IWR-1.==
==Crystal Structure of human Tankyrase 2 in complex with IWR-1.==
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<StructureSection load='4tkf' size='340' side='right' caption='[[4tkf]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='4tkf' size='340' side='right'caption='[[4tkf]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4tkf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TKF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4tkf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TKF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=33C:4-[(3AR,4R,7S,7AS)-1,3-DIOXOOCTAHYDRO-2H-4,7-METHANOISOINDOL-2-YL]-N-(QUINOLIN-8-YL)BENZAMIDE'>33C</scene>, <scene name='pdbligand=3AB:3-AMINOBENZAMIDE'>3AB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pml|4pml]], [[4pnl|4pnl]], [[4pnm|4pnm]], [[4pnn|4pnn]], [[4pnq|4pnq]], [[4pnt|4pnt]], [[4pnr|4pnr]], [[4pns|4pns]], [[4tju|4tju]], [[4tjw|4tjw]], [[4tjy|4tjy]], [[4tk0|4tk0]], [[4tk5|4tk5]], [[4tkg|4tkg]], [[4tki|4tki]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=33C:4-[(3AR,4R,7S,7AS)-1,3-DIOXOOCTAHYDRO-2H-4,7-METHANOISOINDOL-2-YL]-N-(QUINOLIN-8-YL)BENZAMIDE'>33C</scene>, <scene name='pdbligand=3AB:3-AMINOBENZAMIDE'>3AB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkf OCA], [https://pdbe.org/4tkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tkf RCSB], [https://www.ebi.ac.uk/pdbsum/4tkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tkf ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tkf RCSB], [http://www.ebi.ac.uk/pdbsum/4tkf PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
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[https://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4tkf" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Battaile, K P]]
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[[Category: Homo sapiens]]
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[[Category: Beletskaya, I]]
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[[Category: Large Structures]]
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[[Category: Chirgadze, N Y]]
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[[Category: Battaile KP]]
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[[Category: Gebremeskel, S]]
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[[Category: Beletskaya I]]
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[[Category: Gordon, R]]
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[[Category: Chirgadze NY]]
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[[Category: Lam, R]]
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[[Category: Gebremeskel S]]
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[[Category: Pai, E F]]
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[[Category: Gordon R]]
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[[Category: Qiu, W]]
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[[Category: Lam R]]
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[[Category: Romanov, V]]
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[[Category: Pai EF]]
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[[Category: Thompson, C]]
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[[Category: Qiu W]]
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[[Category: Vodsedalek, J]]
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[[Category: Romanov V]]
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[[Category: Transferase]]
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[[Category: Thompson C]]
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[[Category: Vodsedalek J]]

Current revision

Crystal Structure of human Tankyrase 2 in complex with IWR-1.

PDB ID 4tkf

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