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1z3g
From Proteopedia
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==Crystal structure of complex between Pvs25 and Fab fragment of malaria transmission blocking antibody 2A8== | ==Crystal structure of complex between Pvs25 and Fab fragment of malaria transmission blocking antibody 2A8== | ||
| - | <StructureSection load='1z3g' size='340' side='right' caption='[[1z3g]], [[Resolution|resolution]] 3.30Å' scene=''> | + | <StructureSection load='1z3g' size='340' side='right'caption='[[1z3g]], [[Resolution|resolution]] 3.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1z3g]] is a 6 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1z3g]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Plasmodium_vivax_Sal-1 Plasmodium vivax Sal-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z3G FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3g OCA], [https://pdbe.org/1z3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z3g RCSB], [https://www.ebi.ac.uk/pdbsum/1z3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z3g ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/O96555_PLAVI O96555_PLAVI] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/1z3g_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/1z3g_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z3g ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | P25 and P28 proteins are essential for Plasmodium parasites to infect mosquitoes and are leading candidates for a transmission-blocking malaria vaccine. The Plasmodium vivax P25 is a triangular prism that could tile the parasite surface. The residues forming the triangle are conserved in P25 and P28 from all Plasmodium species. A cocrystal structure shows that a transmission-blocking antibody uses only its heavy chain to bind Pvs25 at a vertex of the triangle. | ||
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| - | The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms.,Saxena AK, Singh K, Su HP, Klein MM, Stowers AW, Saul AJ, Long CA, Garboczi DN Nat Struct Mol Biol. 2006 Jan;13(1):90-1. Epub 2005 Dec 4. PMID:16327807<ref>PMID:16327807</ref> | ||
| - | |||
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
==See Also== | ==See Also== | ||
| - | *[[Monoclonal | + | *[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] |
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| - | + | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Garboczi | + | [[Category: Plasmodium vivax Sal-1]] |
| - | [[Category: Klein | + | [[Category: Garboczi DN]] |
| - | [[Category: Long | + | [[Category: Klein MM]] |
| - | [[Category: Saul | + | [[Category: Long CA]] |
| - | [[Category: Saxena | + | [[Category: Saul AJ]] |
| - | [[Category: Singh | + | [[Category: Saxena AK]] |
| - | [[Category: Stowers | + | [[Category: Singh K]] |
| - | [[Category: Su | + | [[Category: Stowers AW]] |
| - | + | [[Category: Su HP]] | |
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| - | + | ||
Current revision
Crystal structure of complex between Pvs25 and Fab fragment of malaria transmission blocking antibody 2A8
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Categories: Large Structures | Mus musculus | Plasmodium vivax Sal-1 | Garboczi DN | Klein MM | Long CA | Saul AJ | Saxena AK | Singh K | Stowers AW | Su HP
