2j40

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[[Image:2j40.jpg|left|200px]]
 
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{{Structure
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==1-pyrroline-5-carboxylate dehydrogenase from Thermus thermophilus with bound inhibitor L-proline and NAD.==
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|PDB= 2j40 |SIZE=350|CAPTION= <scene name='initialview01'>2j40</scene>, resolution 2.10&Aring;
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<StructureSection load='2j40' size='340' side='right'caption='[[2j40]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Na+Binding+Site+For+Chain+B'>AC1</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene> and <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>
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<table><tr><td colspan='2'>[[2j40]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J40 FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/1-pyrroline-5-carboxylate_dehydrogenase 1-pyrroline-5-carboxylate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.12 1.5.1.12]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j40 OCA], [https://pdbe.org/2j40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j40 RCSB], [https://www.ebi.ac.uk/pdbsum/2j40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j40 ProSAT], [https://www.topsan.org/Proteins/RSGI/2j40 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q5SI02_THET8 Q5SI02_THET8]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j4/2j40_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j40 ConSurf].
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<div style="clear:both"></div>
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'''1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE FROM THERMUS THERMOPHILUS WITH BOUND INHIBITOR L-PROLINE AND NAD.'''
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==See Also==
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*[[Pyrroline-5-carboxylate dehydrogenase|Pyrroline-5-carboxylate dehydrogenase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2J40 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J40 OCA].
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[[Category: Large Structures]]
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[[Category: 1-pyrroline-5-carboxylate dehydrogenase]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Single protein]]
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[[Category: Inagaki E]]
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[[Category: Thermus thermophilus]]
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[[Category: Nishio M]]
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[[Category: Inagaki, E.]]
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[[Category: Sakamoto K]]
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[[Category: Nishio, M.]]
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[[Category: Yokoyama S]]
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[[Category: Sakamoto, K.]]
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[[Category: Yokoyama, S.]]
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[[Category: ACT]]
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[[Category: MPD]]
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[[Category: MRD]]
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[[Category: NA]]
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[[Category: NAD]]
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[[Category: PRO]]
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[[Category: 1-pyrroline-5-carboxylate]]
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[[Category: glutamate]]
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[[Category: oxidoreductase]]
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[[Category: proline methabolic pathway]]
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[[Category: type ii hyperprolinmia]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:36:54 2008''
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Current revision

1-pyrroline-5-carboxylate dehydrogenase from Thermus thermophilus with bound inhibitor L-proline and NAD.

PDB ID 2j40

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