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| - | [[Image:2j6j.jpg|left|200px]] | + | #REDIRECT [[5i2s]] This PDB entry is obsolete and replaced by 5i2s |
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| - | {{Structure
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| - | |PDB= 2j6j |SIZE=350|CAPTION= <scene name='initialview01'>2j6j</scene>, resolution 3.000Å
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| - | |SITE= <scene name='pdbsite=AC1:Yb+Binding+Site+For+Chain+A'>AC1</scene>
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| - | |LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> and <scene name='pdbligand=YB:YTTERBIUM (III) ION'>YB</scene>
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| - | |ACTIVITY=
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| - | |GENE=
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| - | }}
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| - | '''PREFUSION FORM OF THE VESICULAR STOMATITIS VIRUS GLYCOPROTEIN G ECTODOMAIN'''
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| - | ==Overview==
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| - | Glycoprotein G of the vesicular stomatitis virus triggers membrane fusion via a low pH-induced structural rearrangement. Despite the equilibrium between the pre- and postfusion states, the structure of the prefusion form, determined to 3.0 angstrom resolution, shows that the fusogenic transition entails an extensive structural reorganization of G. Comparison with the structure of the postfusion form suggests a pathway for the conformational change. In the prefusion form, G has the shape of a tripod with the fusion loops exposed, which point toward the viral membrane, and with the antigenic sites located at the distal end of the molecule. A large number of G glycoproteins, perhaps organized as in the crystals, act cooperatively to induce membrane merging.
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| - | ==About this Structure==
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| - | 2J6J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vesicular_stomatitis_indiana_virus Vesicular stomatitis indiana virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J6J OCA].
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| - | ==Reference==
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| - | Structure of the prefusion form of the vesicular stomatitis virus glycoprotein G., Roche S, Rey FA, Gaudin Y, Bressanelli S, Science. 2007 Feb 9;315(5813):843-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17289996 17289996]
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| - | [[Category: Single protein]]
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| - | [[Category: Vesicular stomatitis indiana virus]]
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| - | [[Category: Bressanelli, S.]]
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| - | [[Category: Rey, F A.]]
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| - | [[Category: Roche, S.]]
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| - | [[Category: NAG]]
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| - | [[Category: YB]]
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| - | [[Category: envelope protein]]
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| - | [[Category: glycoprotein]]
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| - | [[Category: lipoprotein]]
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| - | [[Category: membrane]]
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| - | [[Category: membrane protein]]
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| - | [[Category: transmembrane]]
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| - | [[Category: transmembrane fusion]]
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| - | [[Category: viral protein]]
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| - | [[Category: virion protein]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:37:55 2008''
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