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2j8a

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[[Image:2j8a.jpg|left|200px]]
 
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{{Structure
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==X-ray structure of the N-terminus RRM domain of Set1==
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|PDB= 2j8a |SIZE=350|CAPTION= <scene name='initialview01'>2j8a</scene>, resolution 3.00&Aring;
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<StructureSection load='2j8a' size='340' side='right'caption='[[2j8a]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2j8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J8A FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8a OCA], [https://pdbe.org/2j8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j8a RCSB], [https://www.ebi.ac.uk/pdbsum/2j8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j8a ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SET1_YEAST SET1_YEAST] Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.<ref>PMID:11742990</ref> <ref>PMID:11751634</ref> <ref>PMID:11752412</ref> <ref>PMID:11805083</ref> <ref>PMID:11818070</ref> <ref>PMID:12060701</ref> <ref>PMID:12353038</ref> <ref>PMID:12845608</ref> <ref>PMID:14636589</ref> <ref>PMID:15949446</ref> <ref>PMID:9398665</ref> <ref>PMID:9988274</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j8/2j8a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j8a ConSurf].
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<div style="clear:both"></div>
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'''X-RAY STRUCTURE OF THE N-TERMINUS RRM DOMAIN OF SET1'''
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==See Also==
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2J8A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8A OCA].
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__TOC__
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[[Category: Histone-lysine N-methyltransferase]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Chavez S]]
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[[Category: Chavez, S.]]
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[[Category: Couprie J]]
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[[Category: Couprie, J.]]
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[[Category: Dehe PM]]
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[[Category: Dehe, P M.]]
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[[Category: Geli V]]
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[[Category: Geli, V.]]
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[[Category: Guerois R]]
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[[Category: Guerois, R.]]
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[[Category: Leulliot N]]
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[[Category: Leulliot, N.]]
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[[Category: Luciano P]]
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[[Category: Luciano, P.]]
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[[Category: Pamblanco M]]
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[[Category: Pamblanco, M.]]
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[[Category: Quevillon-Cheruel S]]
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[[Category: Quevillon-Cheruel, S.]]
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[[Category: Rodriguez-Gil A]]
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[[Category: Rodriguez-Gil, A.]]
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[[Category: Salah P]]
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[[Category: Salah, P.]]
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[[Category: Sollier J]]
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[[Category: Sollier, J.]]
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[[Category: Tordera V]]
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[[Category: Tilbeurgh, H Van.]]
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[[Category: Tresaugues L]]
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[[Category: Tordera, V.]]
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[[Category: Van Tilbeurgh H]]
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[[Category: Tresaugues, L.]]
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[[Category: Varlet I]]
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[[Category: Varlet, I.]]
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[[Category: Zinn-Justin S]]
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[[Category: Zinn-Justin, S.]]
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[[Category: chromosomal protein]]
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[[Category: histone methyltransferase]]
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[[Category: methyltransferase]]
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[[Category: nuclear protein]]
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[[Category: rrm fold]]
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[[Category: telomere]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:38:37 2008''
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Current revision

X-ray structure of the N-terminus RRM domain of Set1

PDB ID 2j8a

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