2jam

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[[Image:2jam.gif|left|200px]]
 
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{{Structure
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==Crystal structure of human calmodulin-dependent protein kinase I G==
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|PDB= 2jam |SIZE=350|CAPTION= <scene name='initialview01'>2jam</scene>, resolution 1.70&Aring;
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<StructureSection load='2jam' size='340' side='right'caption='[[2jam]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:J60+Binding+Site+For+Chain+B'>AC1</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene> and <scene name='pdbligand=J60:5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE'>J60</scene>
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<table><tr><td colspan='2'>[[2jam]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JAM FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=J60:5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE'>J60</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jam OCA], [https://pdbe.org/2jam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jam RCSB], [https://www.ebi.ac.uk/pdbsum/2jam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jam ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KCC1G_HUMAN KCC1G_HUMAN] Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/2jam_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jam ConSurf].
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<div style="clear:both"></div>
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'''CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENT PROTEIN KINASE I G'''
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==See Also==
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*[[Calcium/calmodulin dependent protein kinase 3D structures|Calcium/calmodulin dependent protein kinase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2JAM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAM OCA].
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[[Category: Calcium/calmodulin-dependent protein kinase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Unidentified]]
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[[Category: Bullock, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bunkoczi, G.]]
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[[Category: Bullock A]]
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[[Category: Debreczeni, J E.]]
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[[Category: Bunkoczi G]]
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[[Category: Delft, F Von.]]
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[[Category: Debreczeni JE]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Keates, T.]]
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[[Category: Keates T]]
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[[Category: Knapp, S.]]
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[[Category: Knapp S]]
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[[Category: Niesen, F H.]]
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[[Category: Niesen FH]]
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[[Category: Pike, A C.W.]]
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[[Category: Pike ACW]]
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[[Category: Salah, E.]]
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[[Category: Salah E]]
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[[Category: Shrestha, L.]]
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[[Category: Shrestha L]]
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[[Category: Smee, C.]]
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[[Category: Smee C]]
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[[Category: Sobott, F.]]
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[[Category: Sobott F]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom M]]
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[[Category: Turnbull, A.]]
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[[Category: Turnbull A]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: CA]]
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[[Category: Von Delft F]]
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[[Category: EDO]]
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[[Category: J60]]
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[[Category: allosteric enzyme]]
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[[Category: alternative splicing]]
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[[Category: atp-binding]]
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[[Category: calmodulin binding]]
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[[Category: calmodulin-binding]]
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[[Category: golgi apparatus]]
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[[Category: kinase]]
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[[Category: lipoprotein]]
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[[Category: membrane]]
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[[Category: nucleotide binding]]
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[[Category: nucleotide-binding]]
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[[Category: phosphorylation]]
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[[Category: polymorphism]]
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[[Category: prenylation]]
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[[Category: protein serine/threonine kinase]]
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[[Category: serine/threonine-protein kinase]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:39:27 2008''
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Current revision

Crystal structure of human calmodulin-dependent protein kinase I G

PDB ID 2jam

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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