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4wsf

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==Falafel EVH1 domain bound to CENP-C FIM==
==Falafel EVH1 domain bound to CENP-C FIM==
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<StructureSection load='4wsf' size='340' side='right' caption='[[4wsf]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='4wsf' size='340' side='right'caption='[[4wsf]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4wsf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WSF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4wsf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WSF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.501&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wsf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wsf RCSB], [http://www.ebi.ac.uk/pdbsum/4wsf PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wsf OCA], [https://pdbe.org/4wsf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wsf RCSB], [https://www.ebi.ac.uk/pdbsum/4wsf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wsf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PP4R3_DROME PP4R3_DROME]] Regulatory subunit of serine/threonine-protein phosphatase 4. The probable PP4 complex Pp4-19C-PPP4R2r-flfl (PPP4C-PPP4R2-PPP4R3) is required to prevent caspase induced cell death (in vitro). May be involved in DNA damage repair. Key mediator specific for the localization of mira and associated cell fate determinants during both interphase and mitosis. Nuclear Flfl is required to exclude mira/pros from the nucleus when inefficiently bound to the cytoskeleton/cortex, whereas cytosolic or membrane-associated flfl is required for the cortical association and asymmetric localization of mira/pros/brat/stau at metaphase and anaphase.<ref>PMID:16085932</ref> <ref>PMID:18487071</ref> <ref>PMID:19204120</ref>
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[https://www.uniprot.org/uniprot/PP4R3_DROME PP4R3_DROME] Regulatory subunit of serine/threonine-protein phosphatase 4. The probable PP4 complex Pp4-19C-PPP4R2r-flfl (PPP4C-PPP4R2-PPP4R3) is required to prevent caspase induced cell death (in vitro). May be involved in DNA damage repair. Key mediator specific for the localization of mira and associated cell fate determinants during both interphase and mitosis. Nuclear Flfl is required to exclude mira/pros from the nucleus when inefficiently bound to the cytoskeleton/cortex, whereas cytosolic or membrane-associated flfl is required for the cortical association and asymmetric localization of mira/pros/brat/stau at metaphase and anaphase.<ref>PMID:16085932</ref> <ref>PMID:18487071</ref> <ref>PMID:19204120</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4wsf" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lefevre, S R]]
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[[Category: Drosophila melanogaster]]
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[[Category: Singleton, M R]]
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[[Category: Large Structures]]
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[[Category: Phosphatase evh1 domain]]
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[[Category: Lefevre SR]]
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[[Category: Signaling protein]]
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[[Category: Singleton MR]]

Current revision

Falafel EVH1 domain bound to CENP-C FIM

PDB ID 4wsf

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