4rnq
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of tobacco 5-epi-aristolochene synthase (TEAS) with anilinogeranyl diphosphate (AGPP) and geraniline== | |
| - | + | <StructureSection load='4rnq' size='340' side='right'caption='[[4rnq]], [[Resolution|resolution]] 2.47Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4rnq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RNQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RNQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.47Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1GA:GERANILINE'>1GA</scene>, <scene name='pdbligand=A4S:(2E,6E)-3,7-DIMETHYL-8-(PHENYLAMINO)OCTA-2,6-DIEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>A4S</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DPO:DIPHOSPHATE'>DPO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rnq OCA], [https://pdbe.org/4rnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rnq RCSB], [https://www.ebi.ac.uk/pdbsum/4rnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rnq ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Koo | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/5EAS_TOBAC 5EAS_TOBAC] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene. |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Nicotiana tabacum]] | ||
| + | [[Category: Chappell J]] | ||
| + | [[Category: Crenshaw CM]] | ||
| + | [[Category: Koo HJ]] | ||
| + | [[Category: Noel JP]] | ||
| + | [[Category: Spielmann HP]] | ||
| + | [[Category: Starks C]] | ||
Current revision
Crystal structure of tobacco 5-epi-aristolochene synthase (TEAS) with anilinogeranyl diphosphate (AGPP) and geraniline
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